2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBALDEHYDE

Base Information

• Chemical Name: 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBALDEHYDE
• CAS No.: 91301-03-0
• Molecular Formula: C10H7NO2
• Molecular Weight: 173.171
• Hs Code.: 2933499090
• Mol file: 91301-03-0.mol

Synonyms:1,2-Dihydro-2-oxo-3-quinolinecarboxaldehyde;2-Oxo-1,2-dihydroquinoline-3-carbaldehyde;2-Oxo-1,2-dihydroquinoline-3-carboxaldehyde;3-Formyl-2-hydroxyquinoline;3-Formyl-2-quinolone;3-Formylcarbostyril;3-Formylquinolin-2(1H)-one;

Chemical Property of 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 9.17E-08mmHg at 25°C
• Melting Point: >250°C
• Refractive Index: 1.684
• Boiling Point: 434.9 °C at 760 mmHg
• PKA: 10.82±0.70(Predicted)
• Flash Point: 208.7 °C
• PSA: 50.19000
• Density: 1.367g/cm³
• LogP: 1.75290
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxyquinoline-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBALDEHYDE

There total 19 articles about 2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloro-3-quinoline carboxaldehyde (73568-25-9) → 3-formyl-2-quinolone (91301-03-0)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

Reference yield: 91.7%

2-chloro-3-quinoline carboxaldehyde (73568-25-9) → 2-hydroxyquinoline-3-carboxaldehyde (91301-03-0)

Guidance literature:

With hydrogenchloride; water; for 2h; Reflux;

Reference yield: 91.0%

C10H8ClNO → 3-formyl-2-quinolone (91301-03-0)

Guidance literature:

With acetic acid; at 95 ℃; for 8h;

upstream raw materials:

2-chloro-3-quinoline carboxaldehyde

2-quinolone

N,N-dimethyl-formamide

Acetanilid

Downstream raw materials:

2-chloro-3-quinoline carboxaldehyde

1,2-dihydro-1-methyl-2-oxoquinoline-3-carbaldehyde

1-(3-(4-nitrophenyl)prop-2-ynyl)-2-oxo-1,2-dihydroquinoline-3-carbaldehyde

1-(3-(3-nitrophenyl)prop-2-ynyl)-2-oxo-1,2-dihydroquinoline-3-carbaldehyde

Refernces

• 1、 Zhang, Ke,Yang, Zheng-Yin,Wang, Bao-Dui,Sun, Shao-Bo,Li, Ying-Dong,Li, Tian-Rong,Liu, Zeng-Chen,An, Jun-Mei. "A highly selective chemosensor for Al3+ based on 2-oxo-quinoline-3-carbaldehyde Schiff-base". . p. 59 - 63. Retrieved 2014.
• 2、 Senthil Murugan,Vidhyalakshmi,Ramesh,Annaraj. "A Schiff's base receptor for red fluorescence live cell imaging of Zn2+ ions in zebrafish embryos and naked eye detection of Ni2+ ions for bio-Analytical applications". . p. 3195 - 3200. Retrieved 2017.
• 3、 Banerjee,Dash, Subhashree P.,Mohanty, Monalisa,Sanna, Daniele,Sciortino, Giuseppe,Ugone, Valeria,Garribba, Eugenio,Reuter, Hans,Kaminsky, Werner,Dinda. "Chemistry of mixed-ligand oxidovanadium(IV) complexes of aroylhydrazones incorporating quinoline derivatives: Study of solution behavior, theoretical evaluation and protein/DNA interaction". . . Retrieved 2019.
• 4、 Boukhari, Abbes,Djahoudi, Abdelghani,Litim, Bilal,Meliani, Saida. "Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties". . p. 60 - 74. Retrieved 2021/11/09.
• 5、 Bazine, Ismahene,Bendjedid, Samira,Boukhari, Abbes. "Potential antibacterial and antifungal activities of novel sulfamidophosphonate derivatives bearing the quinoline or quinolone moiety". . . Retrieved 2020/12/09.