Fmoc-glycinol

Base Information

• Chemical Name: Fmoc-glycinol
• CAS No.: 105496-31-9
• Molecular Formula: C17H17NO3
• Molecular Weight: 283.327
• Hs Code.: 29242990
• European Community (EC) Number: 626-390-8
• DSSTox Substance ID: DTXSID20384713
• Nikkaji Number: J953.022C
• Wikidata: Q72477834
• Mol file: 105496-31-9.mol

Synonyms:Fmoc-glycinol;105496-31-9;Fmoc-Gly-ol;2-(Fmoc-amino)ethanol;N-Fmoc-ethanolamine;9H-fluoren-9-ylmethyl N-(2-hydroxyethyl)carbamate;n-fmoc-glycinol;(9H-fluoren-9-yl)methyl (2-hydroxyethyl)carbamate;9-Fluorenylmethyl N-(2-hydroxyethyl)carbamate;MFCD00235927;Carbamic acid, (2-hydroxyethyl)-, 9H-fluoren-9-ylmethyl ester;N-fmoc-2-aminoethanol;2-(Fmoc-amino)-1-ethanol;CBiol_000172;Oprea1_812274;SCHEMBL163534;2-(Fmoc-amino)ethanol, 97%;DTXSID20384713;XLIFWDZVNRWYKV-UHFFFAOYSA-N;ICCB2_000172;AKOS009158540;CS-W012249;FD21608;AC-31981;AS-17413;SY047728;2-(9-fluorenylmethoxycarbonyl)aminoethanol;2-(9-Fluorenylmethoxycarbonyl-)aminoethanol;N-(9-fluorenyl-methoxycarbonyl)ethanolamine;F0912;FT-0653696;2-(9H-Fluoren-9-ylmethoxycarbonylamino)ethanol;EN300-331595;M03456;(9H-fluoren-9-yl)methyl 2-hydroxyethylcarbamate;N-(9-Fluorenylmethyloxycarbonyl)-2-aminoethanol;J-001435;2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-1-ethanol;(2-hydroxy-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester;(9H-FLUOREN-9-YL)METHYL N-(2-HYDROXYETHYL)CARBAMATE;carbamic acid,n-(2-hydroxyethyl)-, 9h-fluoren-9-ylmethyl ester

Chemical Property of Fmoc-glycinol

Chemical Property:

• Vapor Pressure: 6.34E-11mmHg at 25°C
• Melting Point: 144-147 °C(lit.)
• Refractive Index: 1.609
• Boiling Point: 502.7 °C at 760 mmHg
• PKA: 11.38±0.46(Predicted)
• Flash Point: 257.8 °C
• PSA: 58.56000
• Density: 1.238 g/cm³
• LogP: 2.90830
• Storage Temp.: 2-8°C
• Solubility.: DMSO, Methanol
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 283.12084340
• Heavy Atom Count: 21
• Complexity: 338

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-Glycinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCO
• Uses: Fmoc-Glycinol is an Fmoc protected amino alcohol. Fmoc-Glycinol is used in the preparation of amphiphilic lactosides.

Technology Process of Fmoc-glycinol

There total 10 articles about Fmoc-glycinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + ethanolamine (141-43-5) → N-(9-fluorenylmethoxycarbonyl)-2-aminoethanol (105496-31-9)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 20 ℃; for 4h;

DOI:10.1021/ja510265e

Reference yield: 98.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + ethanolamine (141-43-5) → N-(9-fluorenylmethoxycarbonyl)-2-aminoethanol (105496-31-9)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 0 - 25 ℃; for 12h;

Reference yield: 87.0%

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) → N-(9-fluorenylmethoxycarbonyl)-2-aminoethanol (105496-31-9)

Guidance literature:

N-(fluoren-9-ylmethoxycarbonyl)glycine; With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate; triphenylphosphine; In neat (no solvent); for 0.166667h; Green chemistry;

With sodium tetrahydroborate; In neat (no solvent); for 0.0833333h; Green chemistry;

DOI:10.1039/c4ra08643k

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

ethanolamine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

N-(fluoren-9-ylmethoxycarbonyl)glycine

Downstream raw materials:

N-fluorenylmethoxycarbonyl-2-amino-1-(4-methoxytriphenylmethoxy)ethane

(9H-fluoren-9-yl)methyl (2-bromoethyl)carbamate

Refernces

• 1、 Liu, Qicai,Ou, Caiwen,Ren, Chunhua,Wang, Ling,Yang, Zhimou,Chen, Minsheng. "A releasable disulfide carbonate linker for molecular hydrogelations". . p. 1556 - 1559. Retrieved 2012.
• 2、 Lee, Chi-Wan,Cao, Hong,Ichiyama, Kozi,Rana, Tariq M.. "Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: Squaryldiamide as a new potential bioisostere of unsubstituted guanidine". . p. 4243 - 4246. Retrieved 2005.
• 3、 -. "Preparation method of triphosphate compound and deoxynucleotide". Paragraph 0107-0109. . Retrieved 2020/11/23.
• 4、 -. "MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS". Paragraph 001283. . Retrieved 2018/09/12.