2'-Aminoacetophenone Hydrochloride

Base Information

• Chemical Name: 2'-Aminoacetophenone Hydrochloride
• CAS No.: 25384-14-9
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Hs Code.: 2922399090
• European Community (EC) Number: 246-930-2
• DSSTox Substance ID: DTXSID1067091
• Mol file: 25384-14-9.mol

Synonyms:25384-14-9;2'-Aminoacetophenone Hydrochloride;1-(2-aminophenyl)ethanone hydrochloride;1-(2-Aminophenyl)ethan-1-one hydrochloride;1-(2-aminophenyl)ethanone;hydrochloride;2'-aminoacetophenone hcl;Ethanone, 1-(2-aminophenyl)-, hydrochloride;EINECS 246-930-2;Ethanone, 1-(2-aminophenyl)-, hydrochloride (1:1);1-(2-aminophenyl)ethanone,hydrochloride;SCHEMBL349545;Ethanone,1-(2-aminophenyl)-, hydrochloride (1:1);1-(2-Aminophenyl)ethanone HCl;DTXSID1067091;AM876;MFCD00035477;1-(2-aminophenyl)ethanonehydrochloride;AKOS015912641;CS-W017640;2'-Aminoacetophenone hydrochloride, 95%;AC-23384;1-(2-Amino-phenyl)-ethanone hydrochloride;FT-0638517;D83209;A817835;W-107240

Chemical Property of 2'-Aminoacetophenone Hydrochloride

Chemical Property:

• Melting Point: 285-289 °C(lit.)
• Boiling Point: 251.8 °C at 760 mmHg
• Flash Point: 106.1 °C
• PSA: 43.09000
• LogP: 2.85460
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 171.0450916
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

99%, ^*data from raw suppliers

2′-Aminoacetophenone hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=CC=C1N.Cl
• Uses: 2'-AMINOACETOPHENONE HYDROCHLORIDE is Usually used in the synthesis of α-benzamidoacetophenone and indazoles. 2′-Aminoacetophenone hydrochloride was used in the synthesis of α-benzamidoacetophenone and indazoles.

Technology Process of 2'-Aminoacetophenone Hydrochloride

There total 3 articles about 2'-Aminoacetophenone Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-acetylnitrobenzene (577-59-3) → 2-aminoacetophenone hydrochloride (25384-14-9)

Guidance literature:

2-acetylnitrobenzene; With hydrogen; C₁₉H₁₂N₄^(2-)*C₂H₆OS*Co⁽²⁺⁾; In ethanol; at 120 ℃; for 15h; under 30003 Torr; Autoclave;

With hydrogenchloride; In diethyl ether; dichloromethane;

DOI:10.1002/ejoc.202100073

Reference yield:

2-aminoacetophenone (551-93-9) → 2-aminoacetophenone hydrochloride (25384-14-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

DOI:10.1021/ol202799j

Reference yield:

→ 2-aminoacetophenone hydrochloride (25384-14-9)

Guidance literature:

o-Aminobenzaldehyd, HCl;

upstream raw materials:

2-acetylnitrobenzene

2-aminoacetophenone

Downstream raw materials:

6-methyl-2-phenyl-4,5-dihydro-furo[2,3-c]acridine

6,7-dihydro-5,8-dimethyldibenzo<1,10>phenanthroline

2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

3-butyl-1-ethyl-5-phenyl-6,7-dihydro-1H-pyrazolo[4,3-e][1,4]diazepin-8-one

Refernces

• 1、 Jierry, Loic,Harthong, Steven,Aronica, Christophe,Mulatier, Jean-Christophe,Guy, Laure,Guy, Stephan. "Efficient dibenzo[c]acridine helicene-like synthesis and resolution: Scaleup, structural control, and high chiroptical properties". supporting information; experimental part. p. 288 - 291. Retrieved 2012/03/22.
• 2、 Jacquignon,Croisy,Ricci,Balucani. "Synthesis and properties of 6H [1]benzopyrano[4,3 b] quinoleines and 6H [1]benzothiapyrano[4,3 b] quinoleines". . p. 3862 - 3871. Retrieved 2007/10/04.