4,6-DIHYDROXY-5-METHYLPYRIMIDINE

Base Information

• Chemical Name: 4,6-DIHYDROXY-5-METHYLPYRIMIDINE
• CAS No.: 63447-38-1
• Molecular Formula: C₅H₆N₂O₂
• Molecular Weight: 126.115
• Hs Code.: 2933599090
• Mol file: 63447-38-1.mol

Synonyms:5-Methyl-4,6-pyrimidinediol;

Chemical Property of 4,6-DIHYDROXY-5-METHYLPYRIMIDINE

Chemical Property:

• Appearance/Colour: White solid
• Melting Point: >300 °C(lit.)
• Boiling Point: 327.4 °C at 760 mmHg
• PKA: 9.41±0.40(Predicted)
• Flash Point: 151.8 °C
• PSA: 66.24000
• Density: 1.44 g/cm³
• LogP: 0.19620
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,6-Dihydroxy-5-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,6-Dihydroxy-5-methylpyrimidine (cas# 63447-38-1) is a compound useful in organic synthesis.

Technology Process of 4,6-DIHYDROXY-5-METHYLPYRIMIDINE

There total 1 articles about 4,6-DIHYDROXY-5-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formamidine hydrochloride (6313-33-3) + Diethyl methylmalonate (609-08-5) → 5-methyl-1H-pyrimidine-4,6-dione (63447-38-1)

Guidance literature:

With sodium ethanolate;

Reference yield:

5-methyl-1H-pyrimidine-4,6-dione (63447-38-1) → 4,6-dichloro-5-methylpyrimidine (4316-97-6)

Guidance literature:

With trichlorophosphate;

Reference yield:

5-methyl-1H-pyrimidine-4,6-dione (63447-38-1) → 6-chloro-5-methylpyrimidin-4-amine (14394-56-0)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

2: ethanol; NH₃

With ethanol; ammonia; trichlorophosphate;

upstream raw materials:

formamidine hydrochloride

Diethyl methylmalonate

Downstream raw materials:

4,6-dichloro-5-methylpyrimidine

6-chloro-5-methylpyrimidin-4-amine