4-Amino-3,5-diiodopyridine

Base Information

• Chemical Name: 4-Amino-3,5-diiodopyridine
• CAS No.: 98136-86-8
• Molecular Formula: C5H4I2N2
• Molecular Weight: 345.91
• Hs Code.: 2933399090
• Mol file: 98136-86-8.mol

Synonyms:Pyridine,4-amino-3,5-diiodo- (6CI);3,5-Diiodopyridin-4-amine;4-Amino-3,5-diiodopyridine;

Chemical Property of 4-Amino-3,5-diiodopyridine

Chemical Property:

• Vapor Pressure: 7.18E-07mmHg at 25°C
• Melting Point: 135-136℃
• Refractive Index: 1.784
• Boiling Point: 408.1 °C at 760 mmHg
• Flash Point: 200.6 °C
• PSA: 38.91000
• Density: 2.679 g/cm³
• LogP: 2.45420
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-3,5-diiodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-3,5-diiodopyridine

There total 1 articles about 4-Amino-3,5-diiodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

4-aminopyridine (504-24-5) → 3-iodopyridin-4-amine (88511-27-7) + 3,4-diiodo-4-aminopyridine (98136-86-8)

Guidance literature:

With iodine; sodium carbonate; potassium iodide; In water; for 16h; Inert atmosphere; Reflux;

DOI:10.1021/jo300481s

Reference yield: 71.0%

3,4-diiodo-4-aminopyridine (98136-86-8) + triphenylsilylacetylene (6229-00-1) → 3,5-bis-[(triphenylsilanyl)-ethynyl]-pyridin-4-ylamine (931104-38-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; Heating;

DOI:10.1016/j.tetlet.2007.01.066

Reference yield: 14.1%

3,4-diiodo-4-aminopyridine (98136-86-8) + para-ethynyl-(4,4,5,5-tetramethyl-4,5-dihydro-1H-3-(N-oxide)-imidazol-1-yloxyl)-phenyl (124774-74-9) → 3,5-bis(4-(4,4,5,5-tetramethyl-2-imidazoline-1-oxyl)phenylethynyl)-4-aminopyridine + 3,5-bis(4-(4,4,5,5-tetramethyl-2-imidazoline-1-oxyl-3-oxide)phenylethynyl)-4-aminopyridine

Guidance literature:

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 20 ℃; for 3h;

DOI:10.1021/ja037157m

upstream raw materials:

4-aminopyridine

Downstream raw materials:

3,5-bis-[(triphenylsilanyl)-ethynyl]-pyridin-4-ylamine

3,5-bis-(2-triphenylsilanyl-ethyl)-pyridin-4-ylamine

5,6,9,10-tetrahydro-4H,8H-pyrido[3,2,1-ij][1,6]naphthyridine

Refernces

• 1、 Livecchi, Marion,Calvet, Geraldine,Schmidt, Frederic. "Palladium-catalyzed synthesis of 2,3-disubstituted 5-azaindoles via heteroannulation reaction and of 2-substituted 5-azaindoles through domino sila-Sonogashira/5-endo cyclization". experimental part. p. 5006 - 5016. Retrieved 2012/07/03.