2-AMINO-4-METHYLOXAZOLE

Base Information

• Chemical Name: 2-AMINO-4-METHYLOXAZOLE
• CAS No.: 35629-70-0
• Molecular Formula: C4H6N2O
• Molecular Weight: 98.1044
• Hs Code.: 29339900
• Mol file: 35629-70-0.mol

Synonyms:4-Methyl-1,3-oxazol-2-amine;4-Methyl-2-aminooxazole;

Chemical Property of 2-AMINO-4-METHYLOXAZOLE

Chemical Property:

• Vapor Pressure: 0.28mmHg at 25°C
• Refractive Index: 1.524
• Boiling Point: 203.24 °C at 760 mmHg
• PKA: 5.80±0.10(Predicted)
• Flash Point: 76.717 °C
• PSA: 52.05000
• Density: 1.168 g/cm³
• LogP: 1.14640
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-methyloxazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-24/25-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4-METHYLOXAZOLE

There total 3 articles about 2-AMINO-4-METHYLOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

CYANAMID (420-04-2) + hydroxy-2-propanone (116-09-6) → 2-amino-4-methyloxazole (35629-70-0)

Guidance literature:

In water; at 45 ℃; for 0.5h;

DOI:10.1016/j.bmc.2007.10.087

Reference yield:

urea (57-13-6) + 1-bromoacetone (598-31-2) → 2-amino-4-methyloxazole (35629-70-0)

Guidance literature:

In ethanol; Heating;

DOI:10.1016/j.bmcl.2005.03.093

Reference yield:

→ 2-amino-4-methyloxazole (35629-70-0)

Guidance literature:

Gemaess J. Med. Chem. 14, 1075 (1971);

upstream raw materials:

CYANAMID

hydroxy-2-propanone

urea

1-bromoacetone

Downstream raw materials:

N-(4-methyl-1,3-oxazol-2-yl)acetamide

2-amino-4-methyl-5-(α-hydroxy-4'-methylbenzyl)oxazole

2-amino-4-methyl-5-(α-hydroxy-2'-chlorobenzyl)oxazole

2-amino-4-methyl-5-(α-hydroxy-4'-p-nitrobenzyl)oxazole

Refernces

• 1、 Ohta, Hiroshi,Ishizaka, Tomoko,Tatsuzuki, Makoto,Yoshinaga, Mitsukane,Iida, Izumi,Yamaguchi, Tomomi,Tomishima, Yasumitsu,Futaki, Nobuko,Toda, Yoshihisa,Saito, Shuji. "Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action". . p. 1111 - 1124. Retrieved 2008/09/17.
• 2、 Crank, George,Khan, Humaid R.. "Formation of Thioamide Derivatives from Reactions of Isothiocyanates with Oxazol-2-amines". . p. 447 - 458. Retrieved 2007/10/02.