(R)-N-FMOC-OCTYLGLYCINE

Base Information

• Chemical Name: (R)-N-FMOC-OCTYLGLYCINE
• CAS No.: 220497-96-1
• Molecular Formula: C25H31 N O4
• Molecular Weight: 409.525
• Mol file: 220497-96-1.mol

Synonyms:FMOC-D-ADEC(2)-OH;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-2-AMINO-DECANOIC ACID;(R)-N-FMOC-OCTYLGLYCINE;(R)-N-(9-FLUORENYLMETHOXYCARBONYL)-2-AMINODECANOIC ACID;(R)-N-FMOC-OCTYLGLYCINE 95%(98%E.E.);(R)-N-fmoc-Octylglycine(e.e.);(R)-N-Fmoc-octylglycine, 95%, ee:98%

Chemical Property of (R)-N-FMOC-OCTYLGLYCINE

Chemical Property:

• Melting Point: 136.5 °C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 529.77°C (rough estimate)
• PSA: 75.63000
• Density: 1.1538 (rough estimate)
• LogP: 6.11980

Purity/Quality:

≥98%, ^*data from raw suppliers

(R)-N-FMOC-OCTYLGLYCINE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-N-FMOC-OCTYLGLYCINE

There total 1 articles about (R)-N-FMOC-OCTYLGLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

D-2-aminodecanoic acid (84276-16-4) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 2-(9H-fluoren-9-ylmethoxycarbonylamino)-decanoic acid (220497-96-1)

Guidance literature:

D-2-aminodecanoic acid; With chloro-trimethyl-silane; In dichloromethane; for 0.25h; Heating;

(fluorenylmethoxy)carbonyl chloride; In dichloromethane; at 20 ℃; for 24h;

With hydrogenchloride; In water; at 20 ℃; for 0.5h; Further stages.;

DOI:10.1021/jo070450a

Reference yield:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-decanoic acid (220497-96-1) + Fmoc-Ala-OH 2-chloro trityl resin + Fmoc-isoleucine (251316-98-0) + Fmoc-Pro-OH (71989-31-6) + N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) → cyclo(-OctGly-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Thr-DVal-Tyr-)

Guidance literature:

Fmoc-Ala-OH 2-chloro trityl resin; With piperidine; In dichloromethane; N,N-dimethyl-formamide; for 0.333333h; copoly(styrene-1percent DVB) polymer matrix Automated synthesizer;

Fmoc-Thr(pg)-OH; With 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 0.666667h; copoly(styrene-1percent DVB) polymer matrix Automated synthesizer;

2-(9H-fluoren-9-ylmethoxycarbonylamino)-decanoic acid; Fmoc-isoleucine; Fmoc-Pro-OH; N-(9-fluorenylmethoxycarbonyl)-D-valine; Fmoc-Thr(pg)-OH; Fmoc-Glu(pg)-OH; Fmoc-Lys(pg)-OH; Fmoc-Gln(pg)-OH; Fmoc-Ser(pg)-OH; Fmoc-Tyr(pg)-OH; Further stages;

Reference yield:

2-(9H-fluoren-9-ylmethoxycarbonylamino)-decanoic acid (220497-96-1) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + Fmoc-isoleucine (251316-98-0) + C41H37ClNO5Pol + Fmoc-Pro-OH (71989-31-6) + N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) → cyclo(-OctGly-Glu-Thr-Ala-Ser-Ile-Pro-Pro-Gln-Lys-Thr-DVal-Lys-)

Guidance literature:

C₄₁H₃₇ClNO₅Pol; With piperidine; In dichloromethane; N,N-dimethyl-formamide; for 0.333333h; copoly(styrene-1percent DVB) polymer matrix Automated synthesizer;

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; With 1-hydroxy-7-aza-benzotriazole; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 0.666667h; copoly(styrene-1percent DVB) polymer matrix Automated synthesizer;

2-(9H-fluoren-9-ylmethoxycarbonylamino)-decanoic acid; Fmoc-isoleucine; Fmoc-Pro-OH; N-(9-fluorenylmethoxycarbonyl)-D-valine; Fmoc-Thr(pg)-OH; Fmoc-Glu(pg)-OH; Fmoc-Lys(pg)-OH; Fmoc-Gln(pg)-OH; Further stages;

upstream raw materials:

D-2-aminodecanoic acid

(fluorenylmethoxy)carbonyl chloride

Refernces