2-(3-Bromopropoxy)tetrahydro-2H-pyran

Base Information

• Chemical Name: 2-(3-Bromopropoxy)tetrahydro-2H-pyran
• CAS No.: 33821-94-2
• Molecular Formula: C8H15BrO2
• Molecular Weight: 223.11
• Hs Code.: 29329900
• European Community (EC) Number: 695-348-9
• DSSTox Substance ID: DTXSID70380745
• Nikkaji Number: J1.431.163G
• Mol file: 33821-94-2.mol

Synonyms:2-(3-Bromopropoxy)tetrahydro-2H-pyran;33821-94-2;2-(3-bromopropoxy)oxane;2-(3-Bromopropoxy)-tetrahydro-2H-pyran;2-(3-BROMOPROPOXY)TETRAHYDROPYRAN;MFCD00058593;1-Bromo-3-(tetrahydropyranyloxy)propane;2H-Pyran, 2-(3-bromopropoxy)tetrahydro-;1-bromo-3-tetrahydropyranyloxypropane;2-(3-Bromo-propoxy)-tetrahydro-pyran;SCHEMBL56755;1-bromo-3-(2-oxanyloxy)propane;AMY9122;DTXSID70380745;HJNHUFQGDJLQRS-UHFFFAOYSA-N;2-(3 -Bromopropoxy)tetrahydropyran;2-(3-bromo-propoxy)tetrahydropyran;2-(3-bromopropoxy) tetrahydropyran;2-(3-bromopropoxy)-tetrahydropyran;2-(3-bromopropyloxy)tetrahydropyran;BCP16875;1-tetrahydropyranyloxy-3-bromopropane;2-(3-bromo-propoxy)-tetrahydropyran;3-bromopropyl tetrahydropyranyl ether;3-Bromo-1-tetrahydropyranyloxypropane;2-(3-bromopropoxy)tetrahyro-2H-pyran;3-bromopropanol tetrahydropyranyl ether;AKOS005215980;AKOS016843885;3-Bromo-1-tetrahydropyranyloxy propane;CS-W008007;DS-4552;1-(tetrahydropyranyloxy)-3-bromopropane;2-(3-bromopropoxyl)tetrahydro-2H-pyran;3-bromopropyl 2-tetrahydropyranyl ether;2-(3-bromo propoxy)tetrahydro-2H-pyran;SY012338;1-(tetrahydropyranyl- oxy)-3-bromopropane;1-bromo-3-(2-tetrahydropyranyl)oxypropane;3-(tetrahydropyran-2-yl)oxypropyl bromide;3-(tetrahydropyran-2-yloxy)propyl bromide;3-bromo-1-(2-tetrahydropyranyloxy)propane;3-bromo-l-(2-tetrahydropyranyloxy)propane;3-bromopropyl-(tetrahydropyran-2-yl)ether;1-bromo-3-(tetrahydropyran-2-yloxy)propane;3-bromo-1-(tetrahydropyran-2-yloxy)propane;rac-2-(3-bromopropoxy)tetrahydro-2h-pyran;rac.-2-(3-bromo-propoxy)-tetrahydro-pyran;(RS)-2-(3-bromo-propoxy)-tetrahydro-pyran;2-(3-bromo-1-propyloxy)tetrahydro-2H-pyran;3-bromo-1-propyl tetrahydro-2-pyranyl ether;A5996;FT-0653015;rac-2-(3-bromopropoxy)-tetrahydro-2h-pyran;2-(3-Bromopropoxy)tetrahydro-2H-pyran, 98%;EN300-133542;J-505768;2-(3-bromopropyloxy)-3,4,5,6-tetrahydro-2H-pyrane

Chemical Property of 2-(3-Bromopropoxy)tetrahydro-2H-pyran

Chemical Property:

• Appearance/Colour: Clear colorless to yellow liquid
• Vapor Pressure: 0.0378mmHg at 25°C
• Refractive Index: n20/D 1.478(lit.)
• Boiling Point: 248.7 °C at 760 mmHg
• Flash Point: 98.6 °C
• PSA: 18.46000
• Density: 1.32 g/cm³
• LogP: 2.31460
• Storage Temp.: −20°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 222.02554
• Heavy Atom Count: 11
• Complexity: 98.1

Purity/Quality:

99% ^*data from raw suppliers

2-(3-Bromopropoxy)tetrahydro-2h-pyran ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)OCCCBr
• Uses: 2-(3-Bromopropoxy)tetrahydro-2H-pyran may be used in organic synthesis studies.

Technology Process of 2-(3-Bromopropoxy)tetrahydro-2H-pyran

There total 1 articles about 2-(3-Bromopropoxy)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-propoxy-tetrahydro-pyran (6581-64-2) → 3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide (33821-94-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine;

DOI:10.1016/S0960-894X(97)00165-0

Reference yield: 100.0%

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide (33821-94-2) + N-cyclopropyl-3-(2,2-dimethyl-1-oxoindan-5-ylamino)-4-methylbenzamide (918335-20-3) → N-cyclopropyl-3-[N-(2,2-dimethyl-1-oxoindan-5-yl)-N-(3-(tetrahydropyran-2-yloxy)propyl)amino]-4-methylbenzamide (918335-47-4)

Guidance literature:

N-cyclopropyl-3-(2,2-dimethyl-1-oxoindan-5-ylamino)-4-methylbenzamide; With 15-crown-5; sodium hydride; In toluene; mineral oil; at 20 ℃; for 0.333333h; Inert atmosphere;

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide; In toluene; mineral oil; at 90 ℃;

Reference yield: 100.0%

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide (33821-94-2) + 6-(2,4-difluorophenylamino)-2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one → 6-[N-(2,4-difluorophenyl)-N-(3-(tetrahydropyran-2-yloxy)propyl)amino]-2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one (918330-54-8)

Guidance literature:

6-(2,4-difluorophenylamino)-2,2-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one; With 15-crown-5; sodium hydride; In toluene; at 20 ℃; for 0.333333h;

3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide; In toluene; at 90 ℃; for 4h;

upstream raw materials:

2-propoxy-tetrahydro-pyran

Downstream raw materials:

hex-2-yne-1,6-diol

ethyl 2-(4-hydroxybutyl)benzoate

3-(tetrahydropyran-2-yloxy)propan-1-ol

1,6-bis(tetrahydropyranyloxy)hexane

Refernces