3-(PYRIMIDIN-2-YL)BENZALDEHYDE

Base Information

• Chemical Name: 3-(PYRIMIDIN-2-YL)BENZALDEHYDE
• CAS No.: 263349-22-0
• Molecular Formula: C11H8 N2 O
• Molecular Weight: 184.197
• Hs Code.: 2933599090
• Mol file: 263349-22-0.mol

Synonyms:3-(PYRIMIDIN-2-YL)BENZALDEHYDE;AKOS BAR-2386;3-(primidin-2-yl)benzaldehyde;Benzaldehyde, 3-(2-pyrimidinyl)- (9CI);3-(4-(Trifluoromethyl)pyrimidin-2-yl)benzaldehyde;3-(4,6-Dimethoxypyrimidin-2-yl)benzaldehyde;3-(4,6-Dimethylpyrimidin-2-yl)benzaldehyde;3-(4-Methoxypyrimidin-2-yl)benzaldehyde

Chemical Property of 3-(PYRIMIDIN-2-YL)BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.012mmHg at 25°C
• Boiling Point: 261.5°Cat760mmHg
• Flash Point: 115.8°C
• PSA: 42.85000
• Density: 1.205g/cm³
• LogP: 1.95610
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-(Pyrimidin-2-yl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(PYRIMIDIN-2-YL)BENZALDEHYDE

There total 5 articles about 3-(PYRIMIDIN-2-YL)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-phenylpyrimidine (7431-45-0) + Bromoform (75-25-2) → 3-(pyrimidin-2-yl)benzaldehyde (263349-22-0)

Guidance literature:

With N-acetylleucine; bis(4-methylisopropylphenyl)ruthenium(II) diacetate; potassium carbonate; In acetonitrile; at 120 ℃; for 24h; Sealed tube; Inert atmosphere;

Reference yield: 60.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + 3-Formylphenylboronic acid (87199-16-4) → 3-(pyrimidin-2-yl)benzaldehyde (263349-22-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; at 90 ℃;

DOI:10.1002/adsc.200900778

Reference yield: 39.0%

3-Formylphenylboronic acid (87199-16-4) + 2-bromopyrimidine (4595-60-2) → 3-(pyrimidin-2-yl)benzaldehyde (263349-22-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; toluene; for 18h; Heating;

DOI:10.1016/S0960-894X(01)00244-X

upstream raw materials:

3-Formylphenylboronic acid

2-bromopyrimidine

2-chloropyrimidine

2-phenylpyrimidine

Downstream raw materials:

4-chloro-3-(pyrimidin-2-yl)benzaldehyde

2,4-dichloro-3-(pyrimidin-2-yl)benzaldehyde

3-(pyrimidin-2-yl)benzonitrile

2-(3-(chloromethyl)phenyl)pyrimidine

Refernces

• 1、 Jia, Chunqi,Wu, Nini,Cai, Xiaofeng,Li, Gang,Zhong, Lei,Zou, Lei,Cui, Xiuling. "Ruthenium-Catalyzed meta-Selective CAr-H Bond Formylation of Arenes". . p. 4536 - 4542. Retrieved 2020/04/09.
• 2、 -. "Preparation method of meta-position cyano-aromatic compound". Paragraph 0007; 0011; 0013. . Retrieved 2020/02/17.