2,3,5,6-TETRACHLOROISONICOTINONITRILE

Base Information

• Chemical Name: 2,3,5,6-TETRACHLOROISONICOTINONITRILE
• CAS No.: 16297-06-6
• Molecular Formula: C₆Cl₄N₂
• Molecular Weight: 241.891
• Mol file: 16297-06-6.mol

Synonyms:Pyridine-4-carbonitrile, 2, 3, 5, 6-tetrachloro-;

Chemical Property of 2,3,5,6-TETRACHLOROISONICOTINONITRILE

Chemical Property:

• Vapor Pressure: 0.00128mmHg at 25°C
• Melting Point: 139-141 °C
• Refractive Index: 1.62
• Boiling Point: 298.3 °C at 760 mmHg
• Flash Point: 134.2 °C
• PSA: 36.68000
• Density: 1.75 g/cm³
• LogP: 3.56688

Purity/Quality:

98%Min ^*data from raw suppliers

2,3,5,6-Tetrachloroisonicotinonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,5,6-TETRACHLOROISONICOTINONITRILE

There total 3 articles about 2,3,5,6-TETRACHLOROISONICOTINONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

pyridine-4-carbonitrile (100-48-1) → 2,3,5,6-tetrachloroisonicotinonitrile (16297-06-6)

Guidance literature:

With phosphorus pentachloride; at 350 ℃; Ni autoclave;

DOI:10.1016/j.jfluchem.2011.05.028

Reference yield:

tetrachloro-isonicotinic acid amide (70593-55-4) → 2,3,5,6-tetrachloroisonicotinonitrile (16297-06-6)

Guidance literature:

With phosphorus pentoxide; unter vermindertem Druck;

Reference yield:

→ 2,3,5,6-tetrachloroisonicotinonitrile (16297-06-6)

Guidance literature:

4-Cyan-pyridin, PCl5;

upstream raw materials:

tetrachloro-isonicotinic acid amide

pyridine-4-carbonitrile

Downstream raw materials:

2,3,5-trichloro-4-cyano-6-morpholinopyridine

2-(trichloro-4-cyanopyridin-2-yl)cyclohexanone

2,3-dichloro-5-(5-chloro-3-oxapentyl)-4-cyano-6,7,8,9-tetrahydro-5H-pyrido<3,2-b>indole

2,3-dichloro-9-(5-chloro-3-oxapentyl)-4-cyano-5,6,7,8-tetrahydro-9H-pyrido<2,3-b>indole

Refernces