nor-(-)-scopolamine

Base Information

• Chemical Name: nor-(-)-scopolamine
• CAS No.: 3292-20-4
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331
• Mol file: 3292-20-4.mol

Synonyms:nor-(-)-scopolamine

Chemical Property of nor-(-)-scopolamine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of nor-(-)-scopolamine

There total 1 articles about nor-(-)-scopolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

scopalamine (138-12-5) → nor-(-)-scopolamine (3292-20-4) + 3-Hydroxy-2-phenyl-propionic acid (1R,2R,4S,5S,7S)-9-formyl-3-oxa-9-aza-tricyclo[3.3.1.02,4]non-7-yl ester (25650-58-2)

Guidance literature:

With oxygen; lithium perchlorate; 9,10-Dicyanoanthracene; In acetonitrile; at 20 ℃; Irradiation;

DOI:10.1016/S0040-4039(00)99299-2

Reference yield: 60.0%

nor-(-)-scopolamine (3292-20-4) + acrylic acid (79-10-7) → nor-(-)-scopolamine-N-β-propionic acid

Guidance literature:

In ethanol; 1.) 70 deg C, 5.7 h, 2.) 20 deg C, 43 h, 3.) 4 deg C, 20 h;

DOI:10.1016/0031-9422(81)84054-X

Reference yield:

nor-(-)-scopolamine (3292-20-4) → nor-(-)-scopolamine-N-β-propionic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / ethanol / 1.) 70 deg C, 5.7 h, 2.) 20 deg C, 43 h, 3.) 4 deg C, 20 h

2: diethyl ether

In diethyl ether; ethanol;

DOI:10.1016/0031-9422(81)84054-X

upstream raw materials:

scopalamine

Refernces