4-(2-TETRAHYDRO-2H-PYRANOXY)PHENYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 4-(2-TETRAHYDRO-2H-PYRANOXY)PHENYLMAGNESIUM BROMIDE
• CAS No.: 36637-44-2
• Molecular Formula: C11H13 Br Mg O2
• Molecular Weight: 281.432
• Hs Code.: 29310099
• Mol file: 36637-44-2.mol

Synonyms:2H-Pyran,tetrahydro-2-phenoxy-, magnesium complex;4-(2-Tetrahydropyranyloxy)phenylmagnesium bromide

Chemical Property of 4-(2-TETRAHYDRO-2H-PYRANOXY)PHENYLMAGNESIUM BROMIDE

Chemical Property:

• Boiling Point: 65 °C
• Flash Point: 1 °F
• PSA: 18.46000
• Density: 0.961 g/mL at 25 °C
• LogP: 3.23780
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-Tetrahydro-2H-pyranoxy)phenylmagnesium bromide solution 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C,F+
• Hazard Codes: F,C,F+,Xn
• Statements: 11-14-19-22-34-40-12-36/37
• Safety Statements: 16-23-26-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(2-Tetrahydro-2H-pyranoxy)phenylmagnesium bromide can be used:In the preparation of C-2 and C-20-diaryl steroidal derivatives.As an intermediate in the synthesis of multiblock copolymers having fullerene backbone for possible applications in photovoltaic devices.

Technology Process of 4-(2-TETRAHYDRO-2H-PYRANOXY)PHENYLMAGNESIUM BROMIDE

There total 1 articles about 4-(2-TETRAHYDRO-2H-PYRANOXY)PHENYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(β-dimethylaminoethoxy)-α-ethyldesoxybenzoin + 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene (36603-49-3) → 1-(p-β-dimethylaminoethoxyphenyl)-1-[p-(2-tetrahydropyranyloxy)phenyl]-2-phenylbutan-1-ol + (4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)magnesium bromide (36637-44-2)

Guidance literature:

With ammonium chloride; In tetrahydrofuran; magnesium;

Reference yield: 95.0%

(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)magnesium bromide (36637-44-2) → C22H26O4

Guidance literature:

With dilithium tetrachlorocuprate; N,N'-di-tert-butyldiaziridinone; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol5030103

Reference yield: 95.0%

2-((2R,6S)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)acetaldehyde (1396205-04-1) + (4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)magnesium bromide (36637-44-2) → 4-(1-hydroxy-2-((2R,6S)-6-(4-methoxyphenyl)tetra-hydro-2H-pyran-2-yl)ethyl)phenol

Guidance literature:

2-((2R,6S)-6-(4-methoxyphenyl)tetrahydro-2H-pyran-2-yl)acetaldehyde; (4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)magnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; for 15h;

DOI:10.1021/jo902167r

upstream raw materials:

4-(tetrahydropyran-2'-yloxy)-1-bromobenzene

Downstream raw materials:

C₂₀H₂₂O₂

C₂₂H₂₆O₂

Acetic acid 4-[1-(4-acetoxy-phenyl)-2-(4-propyl-cyclohexyl)-propenyl]-phenyl ester

Acetic acid 4-[1-(4-acetoxy-phenyl)-2-(4-isopropyl-cyclohexyl)-propenyl]-phenyl ester

Refernces