1-N-BOC-1,3-CYCLOHEXYLDIAMINE

Base Information

• Chemical Name: 1-N-BOC-1,3-CYCLOHEXYLDIAMINE
• CAS No.: 347186-01-0
• Molecular Formula: C11H22 N2 O2
• Molecular Weight: 214.308
• Hs Code.: 2924299090
• Mol file: 347186-01-0.mol

Synonyms:Carbamicacid, (3-aminocyclohexyl)-, 1,1-dimethylethyl ester (9CI);(3-Aminocyclohexyl)carbamic acid tert-butyl ester;N-tert-Butoxycarbonyl-1,3-cyclohexanediamine; tert-Butyl(3-aminocyclohexyl)carbamate; tert-Butyl N-(3-aminocyclohexyl)carbamate

Chemical Property of 1-N-BOC-1,3-CYCLOHEXYLDIAMINE

Chemical Property:

• Boiling Point: 322℃
• PKA: 12.40±0.40(Predicted)
• Flash Point: 149℃
• PSA: 64.35000
• Density: 1.02
• LogP: 2.87220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

96% ^*data from raw suppliers

tert-Butyl3-aminocyclohexylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-1,3-CYCLOHEXYLDIAMINE

There total 5 articles about 1-N-BOC-1,3-CYCLOHEXYLDIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyldicarbonate (34619-03-9) + 1,3-diaminocyclohexane (3385-21-5,26772-34-9,26883-70-5,115092-57-4) → N-(3-aminocyclohexyl)(t-butoxy)carboxamide (347186-01-0,1788036-28-1,609788-04-7,849616-22-4)

Guidance literature:

In chloroform; at 20 ℃;

Reference yield: 53.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,3-diaminocyclohexane (3385-21-5,26772-34-9,26883-70-5,115092-57-4) → N-(3-aminocyclohexyl)(t-butoxy)carboxamide (347186-01-0,1788036-28-1,609788-04-7,849616-22-4)

Guidance literature:

In chloroform; at -5 - 0 ℃; for 6h; Inert atmosphere;

Reference yield: 22.0%

→ 2-tert-butylamino-N-[3-(9-chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)-cyclohexyl]-2-pyridin-3-yl-acetamide (347184-11-6) + N-(3-aminocyclohexyl)(t-butoxy)carboxamide (347186-01-0,1788036-28-1,609788-04-7,849616-22-4)

Guidance literature:

upstream raw materials:

tert-butyldicarbonate

1,3-diaminocyclohexane

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₉H₃₈N₄O₄

Refernces

• 1、 -. "5-Substituted isoquinoline derivatives". Page 97. . Retrieved 2010/02/10.
• 2、 -. "METHODS AND COMPOUNDS FOR INHIBITING MRP1". . . Retrieved 2008/06/13.