benzyl 3-benzyloxy-2-chloropropanimidate

Base Information

• Chemical Name: benzyl 3-benzyloxy-2-chloropropanimidate
• CAS No.: 86522-28-3
• Molecular Formula: C₁₇H₁₈ClNO₂
• Molecular Weight: 303.788
• Mol file: 86522-28-3.mol

Synonyms:benzyl 3-benzyloxy-2-chloropropanimidate

Chemical Property of benzyl 3-benzyloxy-2-chloropropanimidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl 3-benzyloxy-2-chloropropanimidate

There total 1 articles about benzyl 3-benzyloxy-2-chloropropanimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Chloroacrylonitrile (920-37-6) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 3-benzyloxy-2-chloropropanimidate (86522-28-3)

Guidance literature:

With sodium; 5 degC, 1h then r.t., 2 h;

DOI:10.1016/S0040-4020(01)86062-2

Reference yield: 86.0%

benzyl 3-benzyloxy-2-chloropropanimidate (86522-28-3) → benzyl 3-benzyloxy-2-chloropropanoate (86522-27-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86062-2

Reference yield:

benzyl 3-benzyloxy-2-chloropropanimidate (86522-28-3) → O-benzylserine (5445-44-3,32520-12-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / HCl / diethyl ether / 1 h / Ambient temperature

2: 92 percent / sodium azide / Aliquat 336 / H₂O / 9 h / 60 °C

3: 79 percent / H₂ / 10percent Pd/C / ethanol / 8 h

With hydrogenchloride; sodium azide; hydrogen; palladium on activated charcoal; Aliquat 336; In diethyl ether; ethanol; water;

DOI:10.1016/S0040-4020(01)86062-2

upstream raw materials:

2-Chloroacrylonitrile

benzyl alcohol

Downstream raw materials:

benzyl 3-benzyloxy-2-chloropropanoate

O-benzylserine

O-benzyl-DL-serine-benzyl ester hydrochloride

2-Azido-3-benzyloxy-propionic acid-benzyl ester

Refernces