(S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine

Base Information

• Chemical Name: (S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine
• CAS No.: 124798-98-7
• Molecular Formula: C₉H₁₄N₂O₆*C₁₂H₂₃N
• Molecular Weight: 427.541
• Mol file: 124798-98-7.mol

Synonyms:(S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine

Chemical Property of (S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine

There total 3 articles about (S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid benzyl ester (124798-89-6) → (S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine (124798-98-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 3h; Ambient temperature;

DOI:10.1248/cpb.37.1764

Reference yield:

benzyl (S)-dihydroorotate (103300-84-1) → (S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine (124798-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 48.2 percent / t-BuOK / dimethylformamide / 1.5 h / 5 °C

2: 61 percent / hydrogen / 10percent Pd/C / ethanol / 3 h / Ambient temperature

With potassium tert-butylate; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.1764

Reference yield:

L-dihydroorotic acid (5988-19-2,6202-10-4) → (S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid; compound with dicyclohexyl-amine (124798-98-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 59 percent / Et₃N / dimethylformamide / 48 h / Ambient temperature

2: 48.2 percent / t-BuOK / dimethylformamide / 1.5 h / 5 °C

3: 61 percent / hydrogen / 10percent Pd/C / ethanol / 3 h / Ambient temperature

With potassium tert-butylate; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.1764

upstream raw materials:

(S)-1-(2-Methoxy-ethoxymethyl)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid benzyl ester

benzyl (S)-dihydroorotate

L-dihydroorotic acid

Refernces