3-METHYL-1H-INDAZOLE

Base Information

• Chemical Name: 3-METHYL-1H-INDAZOLE
• CAS No.: 3176-62-3
• Molecular Formula: C8H8N2
• Molecular Weight: 132.165
• Hs Code.: 2933990090
• Mol file: 3176-62-3.mol

Synonyms:1H-Indazola,3-methyl- (7CI);3-Methylindazole;

Chemical Property of 3-METHYL-1H-INDAZOLE

Chemical Property:

• Vapor Pressure: 4.49mmHg at 25°C
• Melting Point: 113°C
• Refractive Index: 1.666
• Boiling Point: 147.1 °C at 760 mmHg
• PKA: 14.39±0.40(Predicted)
• Flash Point: 38.6 °C
• PSA: 28.68000
• Density: 1.187 g/cm³
• LogP: 1.87130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Methyl-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYL-1H-INDAZOLE

There total 3 articles about 3-METHYL-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-(2-nitro-phenyl)-ethanone oxime (10342-62-8) → 3-methyl-1H-indazole (3176-62-3) + 2-aminoacetophenone (551-93-9)

Guidance literature:

With carbon monoxide; pentamethylcyclopentadienyl dicarbonyl iron(II) dimer; In 1,4-dioxane; at 150 ℃; for 46h; under 38000 Torr;

DOI:10.3987/com-03-9926

Reference yield: 7.0%

1-(2-aminophenyl)ethanone oxime (4964-49-2) → 3-methyl-1H-indazole (3176-62-3) + 3-(o-aminophenyl)-1,2,5-thiadiazole

Guidance literature:

With tetrasulphur tetranitride; In 1,4-dioxane; for 2.5h; Heating;

Reference yield:

benzimidazole (271-44-3) + methanol (67-56-1) → 1-methyl-1H-indazole (13436-48-1) + 3-methyl-1H-indazole (3176-62-3)

Guidance literature:

With quartz; at 350 ℃; for 5h; under 161891 - 163411 Torr;

DOI:10.1016/j.apcata.2013.03.001

upstream raw materials:

1-(2-aminophenyl)ethanone oxime

1-(2-nitro-phenyl)-ethanone oxime

benzimidazole

methanol

Refernces

• 1、 O'Dell, David K.,Nicholas, Kenneth M.. "Synthesis of 1H-indazoles by reductive cyclization of o-nitro-ketoximes". . p. 373 - 382. Retrieved 2007/10/03.