C₂₀H₂₂N₄O₄

Base Information

• Chemical Name: C₂₀H₂₂N₄O₄
• CAS No.: 917911-02-5
• Molecular Formula: C₂₀H₂₂N₄O₄
• Molecular Weight: 382.419
• Mol file: 917911-02-5.mol

Synonyms:C₂₀H₂₂N₄O₄

Chemical Property of C₂₀H₂₂N₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₂N₄O₄

There total 2 articles about C₂₀H₂₂N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H21N3O5 (917911-01-4) → C20H22N4O4 (917911-02-5)

Guidance literature:

C₂₀H₂₁N₃O₅; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2.5h;

With ammonia; In 1,4-dioxane; water; at 0 - 20 ℃; for 0.25h;

Reference yield:

C24H24N4O7 (1208866-75-4) → C20H22N4O4 (917911-02-5)

Guidance literature:

With ammonia; water; In 1,4-dioxane; at 0 - 20 ℃;

DOI:10.1021/jm100022r

Reference yield: 92.0%

C20H22N4O4 (917911-02-5) + 2-{[(trifluoromethyl)sulfonyl]oxy}cyclohex-1-enecarboxylic acid methyl ester (93493-95-9) → C28H32N4O6 (917911-03-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

DOI:10.1021/jm100022r

upstream raw materials:

C₂₀H₂₁N₃O₅

C₂₄H₂₄N₄O₇

Downstream raw materials:

C₂₈H₃₂N₄O₆

Refernces

• 1、 -. "Niacin receptor agonists, compositions containing such compounds and methods of treatment". Page/Page column 29; 49. . Retrieved 2010/11/25.