2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline

Base Information

• Chemical Name: 2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline
• CAS No.: 853065-37-9
• Molecular Formula: C₁₉H₁₅N
• Molecular Weight: 257.335
• Mol file: 853065-37-9.mol

Synonyms:2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline

Chemical Property of 2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline

There total 8 articles about 2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(E)-3-phenylpropenal (14371-10-9) + 2-methylquinoline (91-63-4) → 2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline (853065-37-9)

Guidance literature:

With cobalt(II) chloride; In water; at 120 ℃; for 48h;

DOI:10.1055/s-0034-1378355

Reference yield: 54.0%

2-methylquinoline (91-63-4) + (2E)-3-phenyl-2-propen-1-ol (4407-36-7) → 2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline (853065-37-9)

Guidance literature:

With potassium tert-butylate; C₂₀H₁₆N₆NiS₄; In toluene; at 110 ℃; for 35h; Inert atmosphere; Schlenk technique;

DOI:10.1002/cctc.202101455

Reference yield: 51.0%

Quinoline N-oxide (1613-37-2) + (E)-buta-1,3-dienylbenzene (16939-57-4) → 2-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)quinoline (853065-37-9)

Guidance literature:

With trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; water; at 120 ℃; for 24h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/c6ob00705h

upstream raw materials:

(E)-3-phenylpropenal

2-methylquinoline

3-phenyl-propenal

4-methyl-N-(3-phenylallylidene)benzenesulfonamide

Downstream raw materials:

2-(4-phenylbutyl)quinoline

Refernces

• 1、 Balamurugan, Gunasekaran,Ramesh, Rengan. "Nickel(II)-Catalyzed Selective (E)-Olefination of Methyl Heteroarenes Using Benzyl Alcohols via Acceptorless Dehydrogenative Coupling Reaction". . . Retrieved 2021/11/30.
• 2、 Crisenza, Giacomo E. M.,Dauncey, Elizabeth M.,Bower, John F.. "C2-Alkenylation of N-heteroaromatic compounds: Via Br?nsted acid catalysis". supporting information. p. 5820 - 5825. Retrieved 2016/07/06.