Technology Process of 1-(4-chlorophenyl)-3,3a,4,8b-tetrahydroindeno[1,2-b]pyrrol-2-one
There total 14 articles about 1-(4-chlorophenyl)-3,3a,4,8b-tetrahydroindeno[1,2-b]pyrrol-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium phosphate; tetrabutylammomium bromide;
copper(I) oxide;
In
water;
at 130 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
1.2: 0 - 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / toluene / 20 h / 110 °C / Inert atmosphere
3.1: trifluoromethylsulfonic anhydride / dichloromethane / 24 h / 20 °C
3.2: 6 h / 70 °C
4.1: dihydrogen peroxide; acetic acid / water / 3 h / 0 °C
5.1: water; sodium hydroxide / 1 h / 100 °C
5.2: 1 h / 20 °C
6.1: sulfuric acid / 2 h / 0 °C
7.1: ammonium acetate / methanol / 0.5 h / Molecular sieve
7.2: 40 h / Reflux
8.1: potassium phosphate; copper(I) oxide; tetrabutylammomium bromide / water / 130 °C
With
copper(I) oxide; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); oxalyl dichloride; trifluoromethylsulfonic anhydride; sulfuric acid; ammonium acetate; tetrabutylammomium bromide; water; dihydrogen peroxide; acetic acid; N,N-dimethyl-formamide; sodium hydroxide;
In
methanol; dichloromethane; water; toluene;
4.1: |Baeyer-Villiger Ketone Oxidation;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / toluene / 20 h / 110 °C / Inert atmosphere
2.1: trifluoromethylsulfonic anhydride / dichloromethane / 24 h / 20 °C
2.2: 6 h / 70 °C
3.1: dihydrogen peroxide; acetic acid / water / 3 h / 0 °C
4.1: water; sodium hydroxide / 1 h / 100 °C
4.2: 1 h / 20 °C
5.1: sulfuric acid / 2 h / 0 °C
6.1: ammonium acetate / methanol / 0.5 h / Molecular sieve
6.2: 40 h / Reflux
7.1: potassium phosphate; copper(I) oxide; tetrabutylammomium bromide / water / 130 °C
With
copper(I) oxide; potassium phosphate; tetrakis(triphenylphosphine) palladium(0); trifluoromethylsulfonic anhydride; sulfuric acid; ammonium acetate; tetrabutylammomium bromide; water; dihydrogen peroxide; acetic acid; sodium hydroxide;
In
methanol; dichloromethane; water; toluene;
3.1: |Baeyer-Villiger Ketone Oxidation;