2-Amino-1-morpholinoethanone hydrochloride

Base Information

• Chemical Name: 2-Amino-1-morpholinoethanone hydrochloride
• CAS No.: 24152-96-3
• Molecular Formula: C6H13ClN2O2
• Molecular Weight: 180.634
• Hs Code.: 2934999090
• European Community (EC) Number: 663-679-8
• DSSTox Substance ID: DTXSID30485023
• Mol file: 24152-96-3.mol

Synonyms:24152-96-3;2-Amino-1-morpholinoethanone hydrochloride;2-amino-1-morpholino-1-ethanone hydrochloride;2-Amino-1-(morpholin-4-yl)ethan-1-one hydrochloride;2-amino-1-morpholin-4-yl-ethanone hcl;2-Amino-1-morpholin-4-yl-ethanone hydrochloride;2-amino-1-morpholin-4-ylethanone;hydrochloride;2-amino-1-(4-morpholinyl)ethanone hydrochloride;MFCD07366740;2-amino-1-morpholino-ethanone hydrochloride;2-Amino-1-morpholin-4-ylethanone hydrochloride;2-AMINO-1-(4-MORPHOLINYL)-ETHANONE HCL;SCHEMBL318833;DTXSID30485023;XNMVLMPXYUXCBV-UHFFFAOYSA-N;ZAA15296;AKOS005071150;4-(Aminoacetyl)morpholine hydrochloride;2-Amino-1-morpholinoethanonehydrochloride;4-(2-aminoacetyl)morpholine hydrochloride;2-Amino-1-morpholin-4-yl-ethanone x HCl;2-AMINO-1-MORPHOLIN-4-ylmethANONE HCl;CS-0199378;FT-0680619;C78088;EN300-126866;7Y-0622;A817117;J-507740;2-Amino-1-(4-morpholinyl)ethanone hydrochloride, 98%;F8889-9399;Z1449750651;Ethanone,2-amino-1-(4-morpholinyl)-,hydrochloride(1:1);2-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)

Chemical Property of 2-Amino-1-morpholinoethanone hydrochloride

Chemical Property:

• Vapor Pressure: 0.000104mmHg at 25°C
• Melting Point: 245-246 °C
• Boiling Point: 332.6 °C at 760 mmHg
• Flash Point: 155 °C
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 180.0665554
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-1-(4-morpholinyl)ethanone hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)CN.Cl

Technology Process of 2-Amino-1-morpholinoethanone hydrochloride

There total 2 articles about 2-Amino-1-morpholinoethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2-morpholin-4-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester (114703-81-0) → 2-amino-1-(morpholin-4-yl)ethanone hydrochloride (24152-96-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; Ambient temperature;

DOI:10.1021/jm00119a015

Reference yield: 44.0%

2-azido-1-(morpholin-4-yl)ethan-1-one (864528-04-1) → 2-amino-1-(morpholin-4-yl)ethanone hydrochloride (24152-96-3)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; In tetrahydrofuran; water; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2017.02.009

Reference yield: 76.0%

2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester (1178896-02-0,1251932-92-9) + 2-amino-1-(morpholin-4-yl)ethanone hydrochloride (24152-96-3) → 2-(5-chloro-6-methyl-3-(2-morpholino-2-oxoethylamino)-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester (1251933-13-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 2.5h; Microwave irradiation; Sealed vial;

DOI:10.1016/j.bmc.2010.06.101

upstream raw materials:

(2-morpholin-4-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester

2-azido-1-(morpholin-4-yl)ethan-1-one

Downstream raw materials:

N-(2-morpholin-4-yl-2-oxo-ethyl)-2-phenyl-acetamide

4-[5-(4-methoxy-phenoxymethyl)-[1,2,3]thiadiazole-4-carbonyl]-morpholine

4-[5-(3,4-dichloro-phenoxymethyl)-[1,2,3]thiadiazole-4-carbonyl]-morpholine

4-(5-phenoxymethyl-[1,2,3]thiadiazole-4-carbonyl)-morpholine

Refernces

• 1、 Johansson, Henrik,Boesgaard, Michael Worch,N?rskov-Lauritsen, Lenea,Larsen, Inna,Kuhne, Sebastiaan,Gloriam, David E.,Br?uner-Osborne, Hans,Sejer Pedersen, Daniel. "Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold". . p. 8938 - 8951. Retrieved 2015/12/09.