2-Amino-N,N-dimethylacetamide hydrochloride

Base Information

• Chemical Name: 2-Amino-N,N-dimethylacetamide hydrochloride
• CAS No.: 72287-77-5
• Molecular Formula: C4H11ClN2O
• Molecular Weight: 138.597
• Hs Code.: 2924199090
• European Community (EC) Number: 813-849-4
• DSSTox Substance ID: DTXSID80602768
• Mol file: 72287-77-5.mol

Synonyms:2-Amino-N,N-dimethylacetamide hydrochloride;72287-77-5;MFCD08060117;N,N-Dimethylglycinamide hydrochloride;Acetamide, 2-amino-N,N-dimethyl-, monohydrochloride;2-amino-N,N-dimethylacetamide;hydrochloride;2-Amino-n,n-dimethylacetamide, HCl;2-AMINO-N,N-DIMETHYLACETAMIDE HCL;2-Amino-N,N-dimethylacetamidehydrochloride;2-amino-N,N-dimethylacetamide,hydrochloride;2-amino-n,n-dimethyl-acetamide hydrochloride;SCHEMBL891027;DTXSID80602768;MXDZKEPRCKHSCM-UHFFFAOYSA-N;BCP23239;N,N-dimethylglycineamide hydrochloride;AKOS005071151;CS-W003959;SY109935;DB-002110;AM20100689;EN300-30695;7Y-0624;A847783;N,N-Dimethylglycinamide--hydrogen chloride (1/1);2-Amino-N pound notN-dimethylacetamide hydrochloride;Q-103483

Chemical Property of 2-Amino-N,N-dimethylacetamide hydrochloride

Chemical Property:

• Vapor Pressure: 0.0946mmHg at 25°C
• Boiling Point: 220.1 °C at 760 mmHg
• Flash Point: 86.9 °C
• PSA: 46.33000
• LogP: 0.53560
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 138.0559907
• Heavy Atom Count: 8
• Complexity: 70.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-N,N-dimethylacetamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)CN.Cl

Technology Process of 2-Amino-N,N-dimethylacetamide hydrochloride

There total 3 articles about 2-Amino-N,N-dimethylacetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate (3392-07-2) + dimethyl amine (124-40-3) → 2-amino-N,N-dimethyl-acetamide hydrochloride (72287-77-5)

Guidance literature:

With hydrogenchloride; water; In acetonitrile; for 3h; Ambient temperature;

DOI:10.1248/cpb.32.609

Reference yield:

N-[2-(dimethylamino)-2-oxoethyl]carbamic acid 1,1-dimethylethyl ester (72287-76-4) → 2-amino-N,N-dimethyl-acetamide hydrochloride (72287-77-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/ja00063a046

Reference yield:

→ 2-amino-N,N-dimethyl-acetamide hydrochloride (72287-77-5)

Guidance literature:

upstream raw materials:

N-[2-(dimethylamino)-2-oxoethyl]carbamic acid 1,1-dimethylethyl ester

tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate

dimethyl amine

Downstream raw materials:

2-[2-(3-butoxyphenyl)ethylamino]-N,N-dimethylacetamide

2-benzylideneamino-N,N-dimethylacetamide

2-(5-chloro-3-(2-(dimethylamino)-2-oxoethylamino)-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

Refernces

• 1、 Diener, Matthew E.,Metrano, Anthony J.,Kusano, Shuhei,Miller, Scott J.. "Enantioselective Synthesis of 3-Arylquinazolin-4(3H)-ones via Peptide-Catalyzed Atroposelective Bromination". supporting information. p. 12369 - 12377. Retrieved 2015/10/12.
• 2、 Hayashi, Takashi,Asai, Tomohito,Ogoshi, Hisanobu. "Conformational analysis of β-turn structure in tetrapeptides containing proline or proline analogs". . p. 3039 - 3042. Retrieved 2007/10/03.