3-Bromo-5-chloro-2-hydroxypyridine

Base Information

• Chemical Name: 3-Bromo-5-chloro-2-hydroxypyridine
• CAS No.: 137628-16-1
• Molecular Formula: C5H3BrClNO
• Molecular Weight: 208.442
• Hs Code.: 2933399090
• European Community (EC) Number: 862-430-2
• DSSTox Substance ID: DTXSID80369420
• Wikidata: Q72452704
• Mol file: 137628-16-1.mol

Synonyms:3-Bromo-5-chloro-2-hydroxypyridine;137628-16-1;3-bromo-5-chloropyridin-2-ol;3-bromo-5-chloro-1H-pyridin-2-one;3-bromo-5-chloro-pyridin-2-ol;3-bromo-5-chloropyridin-2(1H)-one;2(1H)-Pyridinone, 3-bromo-5-chloro-;MFCD01764522;3-BROMO-5-CHLORO-2-PYRIDINOL;SCHEMBL1619095;3-Bromo-5-chloropyridin-2-one;AMY2756;DTXSID80369420;3-bromo-5-chloro-lH-2-pyridone;IPCVJZRBMDESEV-UHFFFAOYSA-N;3-bromo-5-chloro-1H-2-pyridone;3-bromo-5-chloro-2(1h)-pyridinone;AKOS007930309;AKOS015950843;AB09921;AC-6255;CS-W000824;SY047612;TS-02974;FT-0658515;EN300-114650;H11346;A807287;J-511994;Z1269191046

Chemical Property of 3-Bromo-5-chloro-2-hydroxypyridine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.629
• Boiling Point: 294.33 °C at 760 mmHg
• PKA: 8.48±0.10(Predicted)
• Flash Point: 131.807 °C
• PSA: 33.12000
• Density: 1.908 g/cm³
• LogP: 2.20310
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 206.90865
• Heavy Atom Count: 9
• Complexity: 209

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-BROMO-5-CHLORO-2-HYDROXYPYRIDINE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=O)NC=C1Cl)Br

Technology Process of 3-Bromo-5-chloro-2-hydroxypyridine

There total 5 articles about 3-Bromo-5-chloro-2-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-amino-3-bromo-5-chloropyridine (26163-03-1) → 3-bromo-5-chloro-2-hydroxypyridine (137628-16-1)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; for 18h; Ambient temperature;

DOI:10.1021/jo00032a060

Reference yield: 69.0%

2-amino-3-bromo-5-chloropyridine (26163-03-1) → 3-bromo-5-chloro-1H-2-pyridone (137628-16-1)

Guidance literature:

With sodium nitrite; In water;

Reference yield: 66.0%

5-chloro-2-pyridinol (4214-79-3) → 3-bromo-5-chloro-2-hydroxypyridine (137628-16-1)

Guidance literature:

5-chloro-2-pyridinol; With bromine; In acetic acid; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water; ethyl acetate;

upstream raw materials:

2-amino-3-bromo-5-chloropyridine

5-chloro-2-pyridinol

5-chloro-2-pyridylamine

Downstream raw materials:

2,3-dibromo-5-chloro-pyridine

2-(benzyloxy)-3-bromo-5-chloropyridine

2-Pyridone

5-chloro-2-hydroxynicotinaldehyde

Refernces

• 1、 -. "AMINONITRILES AS KYNURENINE PATHWAY INHIBITORS". Page/Page column 83; 84. . Retrieved 2014/09/29.
• 2、 -. "2,3'-BIPYRIDINES DERIVATIVES AS SELECTIVE COX-2 INHIBITORS". Page 11. . Retrieved 2008/06/13.