6-AMINO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

Base Information

• Chemical Name: 6-AMINO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• CAS No.: 72299-67-3
• Molecular Formula: C9H12 N2
• Molecular Weight: 148.208
• Hs Code.: 2933499090
• Mol file: 72299-67-3.mol

Synonyms:6-AMINO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;1,2,3,4-TETRAHYDROISOQUINOLIN-6-AMINE;1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YLAMINE

Chemical Property of 6-AMINO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 315.903°C at 760 mmHg
• PKA: 10.17±0.20(Predicted)
• Flash Point: 169.23°C
• PSA: 38.05000
• Density: 1.101g/cm³
• LogP: 1.82450
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,2,3,4-tetrahydroisoquinolin-6-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-AMINO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

There total 6 articles about 6-AMINO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2,3,4-tetrahydroisoquinolin-6-amine dihydrobromide → 1,2,3,4-tetrahydroisoquinolin-6-amine (72299-67-3)

Guidance literature:

With sodium hydroxide; In water;

Reference yield: 99.0%

6-isoquinolinamine (23687-26-5) → 1,2,3,4-tetrahydroisoquinolin-6-amine (72299-67-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In ethanol; water; Flow reactor; Heating;

DOI:10.1002/ejoc.201801684

Reference yield:

tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (164148-92-9) → 1,2,3,4-tetrahydroisoquinolin-6-amine (72299-67-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1.5h;

upstream raw materials:

6-amino-3,4-dihydro-isoquinoline-1(2H)-one

6-isoquinolinamine

tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

7-nitro-1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

6-[[4-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]benzoyl]amino]-1,2,3,4-tetrahydroisoquinolineacetic acid 1,1-dimethylethyl ester

6-[(4-cyanobenzoyl)amino]-1,2,3,4-tetrahydroisoquinolineacetic acid 1,1-dimethylethyl ester

Refernces

• 1、 -. "NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS". Page/Page column 19; 20. . Retrieved 2015/04/28.
• 2、 -. "Bronchorelaxing agents based on indol- and isoquinoline derivatives". Page/Page column 13-15. . Retrieved 2010/11/25.