N-[2-(piperidin-1-yl)ethyl]aniline

Base Information

• Chemical Name: N-[2-(piperidin-1-yl)ethyl]aniline
• CAS No.: 5319-52-8
• Molecular Formula: C₁₃H₂₀N₂
• Molecular Weight: 204.315
• Mol file: 5319-52-8.mol

Synonyms:N-[2-(piperidin-1-yl)ethyl]aniline

Chemical Property of N-[2-(piperidin-1-yl)ethyl]aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(piperidin-1-yl)ethyl]aniline

There total 9 articles about N-[2-(piperidin-1-yl)ethyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

piperidine (110-89-4) + N-phenyl-2-oxazolidinone (703-56-0) → N-[2-(piperidin-1-yl)ethyl]aniline (5319-52-8)

Guidance literature:

In dimethyl sulfoxide; at 110 ℃; for 168h;

DOI:10.1055/s-2007-983810

Reference yield: 48.0%

N-chloroethylpiperidine hydrochloride (2008-75-5) + aniline (62-53-3) → N-[2-(piperidin-1-yl)ethyl]aniline (5319-52-8)

Guidance literature:

In neat (no solvent); at 130 ℃; for 72h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.orglett.9b02515

Reference yield: 32.0%

1-piperidinoethanol (3040-44-6) + aniline (62-53-3) → N-[2-(piperidin-1-yl)ethyl]aniline (5319-52-8)

Guidance literature:

With C₁₉H₂₂MnN₃O₃P⁽¹⁺⁾; potassium hydride; In 1,2-dimethoxyethane; at 80 ℃; for 24h; Glovebox; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00832

upstream raw materials:

piperidine

N-(2-chloroethyl)aniline hydrochloride

2-(piperidin-4-yl)ethyl chloride

aniline

Downstream raw materials:

N-(1H-benzimidazol-2-ylmethyl)-N-(2-piperidino-ethyl)-aniline

3-(4-Chlorphenyl)-4-phenyl-5-(2-piperidinoethylanilino)isoxazol

3-(4-Chlorphenyl)-5-(2-piperidinoethylanilino)isoxazol

N-(2-piperidino-ethyl)-acetanilide

Refernces

• 1、 You, Wei,Hugar, Kristina M.,Selhorst, Ryan C.,Treichel, Megan,Peltier, Cheyenne R.,Noonan, Kevin J. T.,Coates, Geoffrey W.. "Degradation of Organic Cations under Alkaline Conditions". supporting information. p. 254 - 263. Retrieved 2020/12/23.
• 2、 Morita, Yasuhiro,Ishigaki, Takeshi,Kawamura, Kuniaki,Iseki, Katsuhiko. "Short and practical synthesis of N′,N′-disubstituted N-aryl-1,2-ethylene-diamines by a decarboxylative ring-opening reaction under nucleophilic conditions". . p. 2517 - 2523. Retrieved 2008/02/13.