4,5-DIHYDRO-FURAN-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 4,5-DIHYDRO-FURAN-3-CARBOXYLIC ACID
• CAS No.: 98021-62-6
• Molecular Formula: C5H6O3
• Molecular Weight: 114.101
• Hs Code.: 2932190090
• Mol file: 98021-62-6.mol

Synonyms:3-Furoicacid, 4,5-dihydro- (6CI);

Chemical Property of 4,5-DIHYDRO-FURAN-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.0334mmHg at 25°C
• Refractive Index: 1.53
• Boiling Point: 224.5 °C at 760 mmHg
• Flash Point: 100.7 °C
• PSA: 46.53000
• Density: 1.369 g/cm³
• LogP: 0.37520

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,5-Dihydrofuran-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DIHYDRO-FURAN-3-CARBOXYLIC ACID

There total 6 articles about 4,5-DIHYDRO-FURAN-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-trichloroacetyl-4,5-dihydrofuran (83124-80-5) → 4,5-dihydrofuran-3-carboxylic acid (98021-62-6)

Guidance literature:

With potassium hydroxide; water; In benzene; for 5h; Heating;

DOI:10.1055/s-1986-31854

Reference yield: 81.0%

4-trifluoroacetyl-2,3-dihydrofuran (109317-75-1) → 4,5-dihydrofuran-3-carboxylic acid (98021-62-6)

Guidance literature:

With potassium hydroxide; water; In benzene; for 5h; Heating;

DOI:10.1055/s-1986-31854

Reference yield:

4,5-dihydro-3-carboxylic acid chloride (117943-06-3) → 4,5-dihydrofuran-3-carboxylic acid (98021-62-6)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

4,5-dihydro-3-carboxylic acid chloride

4,5-dihydro-furan-3-carboxylic acid methyl ester

4-trifluoroacetyl-2,3-dihydrofuran

3-trichloroacetyl-4,5-dihydrofuran

Downstream raw materials:

4-hydroxybutyraldehyde

4,5-Dihydro-furan-3-carboxylic acid (4-chloro-phenyl)-amide

4,5-Dihydro-3-furoanilid

4,5-Dihydro-furan-3-carboxylic acid (3,4-dichloro-phenyl)-amide

Refernces

• 1、 Hojo, Masaru,Masuda, Ryoichi,Sakaguchi, Syuhei,Takagawa, Makoto. "A Convenient Synthetic Method for β-Alkoxy- and β-Phenoxyacrylic Acids and 3,4-Dihydro-2H-pyran-5- and 2,3-Dihydrofuran-4-carboxylic Acids". . p. 1016 - 1017. Retrieved 2007/10/02.