3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOLE-2-CARBALDEHYDE

Base Information

• Chemical Name: 3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOLE-2-CARBALDEHYDE
• CAS No.: 101125-34-2
• Molecular Formula: C18H16FNO
• Molecular Weight: 281.33
• Hs Code.: 2933990090
• Mol file: 101125-34-2.mol

Synonyms:3-(4-Fluorophenyl)-1-isopropyl-1H-indole-2-carboxaldehyde;2-Formyl-3-(4-fluorophenyl)-1-N-isopropyl indole;

Chemical Property of 3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOLE-2-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 2.74E-08mmHg at 25°C
• Melting Point: 90-91℃ (isopropanol )
• Refractive Index: 1.582
• Boiling Point: 450 °C at 760 mmHg
• Flash Point: 225.9 °C
• PSA: 22.00000
• Density: 1.14 g/cm³
• LogP: 4.84080
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

1-Isopropyl-3-(4-fluorophenyl)indole-2-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fluvastatin (F601250) intermediate. 1-Isopropyl-3-(4-fluorophenyl)indole-2-carboxaldehyde (Fluvastatin EP Impurity G) is a Fluvastatin (F601250) intermediate.

Technology Process of 3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOLE-2-CARBALDEHYDE

There total 9 articles about 3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOLE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-(4'-fluorophenyl)-1-(1'-methylethyl)-1H-indole (93957-49-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2-carboxaldehyde (101125-34-2)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; for 16h;

DOI:10.1016/S0040-4039(00)98949-4

Reference yield: 52.0%

Dichloromethyl methyl ether (4885-02-3) + 3-(4'-fluorophenyl)-1-(1'-methylethyl)-1H-indole (93957-49-4) → 3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2-carboxaldehyde (101125-34-2)

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 4.5h; Heating;

DOI:10.1016/S0040-4039(00)98949-4

Reference yield: 39.0%

3-(4'-fluorophenyl)-1-(1'-methylethyl)-1H-indole (93957-49-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2-carboxaldehyde (101125-34-2) + 3-(4-Fluoro-phenyl)-1-isopropyl-1H-indole-7-carbaldehyde (101125-36-4) + 3-(4-Fluoro-phenyl)-1-isopropyl-1H-indole-5-carbaldehyde (101125-35-3)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 18h;

DOI:10.1016/S0040-4039(00)98949-4

upstream raw materials:

Dichloromethyl methyl ether

3-(4'-fluorophenyl)-1-(1'-methylethyl)-1H-indole

N,N-dimethyl-formamide

N-Isopropylaniline

Downstream raw materials:

3,5-bis-ethoxycarbonyloxy-5-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-pent-2-enoic acid methyl ester

(E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide

5-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxypent-2-enoic acid methyl ester

tert-butyl 2-((4R,6S)-6-((E)-2-(3-(4-fluorophenyl)-1-isopropylindol-2-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Refernces

• 1、 -. "Process for the preparation of indole derivatives and intermediates of the process". . . Retrieved 2008/06/13.
• 2、 -. "PHOSPHORUS-CONTAINING HMG-COA REDUCTASE INHIBITORS, NEW INTERMEDIATES AND METHOD". . . Retrieved 2008/06/13.