Technology Process of 1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-tetrazol-1-yl]methyl}-1-pyrrolidinecarboxylate
There total 6 articles about 1,1-dimethylethyl (3R)-3-{[5-(4-bromophenyl)-1H-tetrazol-1-yl]methyl}-1-pyrrolidinecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trimethylsilylazide; di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 25 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 25 °C
1.2: 20 °C / Cooling with ice
2.1: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C
With
oxalyl dichloride; trimethylsilylazide; di-isopropyl azodicarboxylate; N,N-dimethyl-formamide; triphenylphosphine;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide / 100 °C / Inert atmosphere
3.1: triethylamine; hydrogen / ethanol / 20 °C / 2585.81 - 3102.97 Torr / Inert atmosphere
4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 25 °C
4.2: 20 °C / Cooling with ice
5.1: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 °C
With
oxalyl dichloride; trimethylsilylazide; di-isopropyl azodicarboxylate; hydrogen; triethylamine; N,N-dimethyl-formamide; triphenylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;