4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylic acid

Base Information

• Chemical Name: 4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylic acid
• CAS No.: 167690-53-1
• Molecular Formula: C23H25NO4
• Molecular Weight: 379.456
• Hs Code.: 29242990
• European Community (EC) Number: 847-117-0
• Nikkaji Number: J1.884.836H
• Mol file: 167690-53-1.mol

Synonyms:167690-53-1;188715-40-4;Fmoc-4-Amc-OH;FMOC-TRANEXAMIC ACID;4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylic acid;4-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]cyclohexane-1-carboxylic Acid;trans-4-(Fmoc-aminomethyl)cyclohexanecarboxylic acid;Fmoc-trans-4-(aminomethyl)-cyclohexane-1-carboxylic acid;Fmoc-(4-aminomethyl)-cyclohexane carboxylic acid;trans-4-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylic acid;trans-4-[[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]methyl]cyclohexanecarboxylic acid;4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-methyl)cyclohexanecarboxylic acid;N-Fmoc-tranexamic acid;MFCD00273480;(1r,4r)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid;trans-4-({[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}methyl)cyclohexanecarboxylic acid;Trans-4-[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl]cyclohexanecarboxylic acid;Fmoc-trans-4-Amc-OH;tran-4-(fmoc-aminomethyl)cyclohexanecarboxylic acid;SCHEMBL119618;SCHEMBL800277;SCHEMBL14508319;MLMIBGARTUSGND-WKILWMFISA-N;AKOS015910380;AKOS016010490;DS-4815;GS-6399;Cyclohexanecarboxylic acid, 4-[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl]-, trans-;CS-0067149;CS-0187427;F1215;FT-0679733;D70277;EN300-312399;EN300-649781;H10418;A880506;fmoc-trans-4-(aminomethyl)cyclohexanecarboxylic acid;J-010388;Z1793620650;Fmoc-(4-aminomethyl)-cyclohexane carboxylic acid, AldrichCPR;TRANS-4-(9-FLUORENYLMETHYLOXYCARBONYLAMINOMETHYL)-CYCLOHEXANOIC ACID;trans-4-(Fmoc-aminomethyl)cyclohexanecarboxylic acid, >=98.0% (HPLC);(1r,4r)-4-((((9H-fluoren-9-yl)methoxy)carbonylamino)methyl)cyclohexanecarboxylic acid;4-[({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)METHYL]CYCLOHEXANE-1-CARBOXYLIC ACID;4alpha-(9H-Fluorene-9-ylmethoxycarbonylaminomethyl)cyclohexane-1beta-carboxylic acid;Cyclohexanecarboxylic acid, 4-[[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]methyl]-;trans-4-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylicacid

Chemical Property of 4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylic acid

Chemical Property:

• Melting Point: 188 °C
• Boiling Point: 604.9 °C at 760 mmHg
• PKA: 4.85±0.10(Predicted)
• Flash Point: 319.6 °C
• PSA: 75.63000
• Density: 1.226 g/cm³
• LogP: 4.80700
• Storage Temp.: 2-8°C
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 379.17835828
• Heavy Atom Count: 28
• Complexity: 535

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-tranexamicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CCC1CNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

Technology Process of 4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylic acid

There total 1 articles about 4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (1R,4R)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid (167690-53-1)

Guidance literature:

trans-4-aminomethyl-cyclohexyl-carboxylic acid; With triethylamine; In water; at 20 ℃;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In water; acetonitrile; at 20 ℃;

DOI:10.1021/op010204f

Reference yield: 98.55%

nicotinic acid (59-67-6) + (1R,4R)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid (167690-53-1) → N-(Nicotinoyl)-trans-4-aminomethylcyclohexanecarboxylic acid (114681-67-3)

Guidance literature:

(1r,4r)-4-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexane-1-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; for 1h;

In N,N-dimethyl-formamide; for 1h;

nicotinic acid; Further stages;

Reference yield: 72.0%

di-tert-butyl (2S)-2-({[(2S)-6-{[(2S)-2-amino-3-(3,4,5-trifluorophenyl)propanoyl]amino}-1-tert-butoxy-1-oxohexan-2-yl]carbamoyl}amino)pentanedioate + (1R,4R)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid (167690-53-1) → tri-tert-butyl (3S,10S,14S)-1-{(1r,4S)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}-1,4,12-trioxo-3-[(3,4,5-trifluorophenyl)methyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylate

Guidance literature:

With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 18 - 25 ℃; Inert atmosphere;

upstream raw materials:

trans-4-aminomethyl-cyclohexyl-carboxylic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

(4-isocyanato-cyclohexylmethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

C₃₄H₄₂FN₇O₄

C₃₅H₄₂F₃N₇O₄

C₃₄H₄₃N₇O₄

Refernces

• 1、 -. "NOVEL MATERIAL FOR SKIN WHITENING, COMPOSITION COMPRISING THE SAME AND METHODS FOR MANUFACTURING THE SAME". Paragraph 0046; 0048; 0049. . Retrieved 2020/05/19.
• 2、 Boatman, P. Douglas,Urban, Jan,Nguyen, Minh,Qabar, Maher,Kahn, Michael. "High-throughput synthesis and optimization of thrombin inhibitors via urazole α-addition and Michael addition". . p. 1445 - 1449. Retrieved 2007/10/03.