N-phenyl-[1,1’-biphenyl]-4-carboxamide

Base Information

• Chemical Name: N-phenyl-[1,1’-biphenyl]-4-carboxamide
• CAS No.: 112561-32-7
• Molecular Formula: C₁₉H₁₅NO
• Molecular Weight: 273.334
• Mol file: 112561-32-7.mol

Synonyms:N-phenyl-[1,1’-biphenyl]-4-carboxamide

Chemical Property of N-phenyl-[1,1’-biphenyl]-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenyl-[1,1’-biphenyl]-4-carboxamide

There total 13 articles about N-phenyl-[1,1’-biphenyl]-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

aniline (62-53-3) + biphenyl-4-carboxylic acid (92-92-2) → N-phenyl-[1,1’-biphenyl]-4-carboxamide (112561-32-7)

Guidance literature:

With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1039/c9ob00699k

Reference yield: 86.0%

1-([1,1'-biphenyl]-4-carbonyl)pyrrolidin-2-one + aniline (62-53-3) → N-phenyl-[1,1’-biphenyl]-4-carboxamide (112561-32-7)

Guidance literature:

With di-tert-butyl peroxide; tetra-(n-butyl)ammonium iodide; In water; for 16h; Heating; Green chemistry;

DOI:10.1039/d1ob00967b

Reference yield: 81.0%

N-methyl-N-phenyl-[1,1'-biphenyl]-4-carboxamide (349407-14-3) + aniline (62-53-3) → N-phenyl-[1,1’-biphenyl]-4-carboxamide (112561-32-7)

Guidance literature:

With manganese; chloro-trimethyl-silane; C₃₇H₅₀NO₄P; nickel dichloride; In 1-methyl-pyrrolidin-2-one; at 160 ℃;

DOI:10.1039/d0ob01271h

upstream raw materials:

4-phenyl-benzophenone-seqcis-oxime

4-phenyl-benzophenone-seqtrans-oxime

aniline

biphenyl-4-carboxylic acid

Downstream raw materials:

N-(4-fluorophenyl)-[1,1'-biphenyl]-4-carboxamide

N-phenyl-4-phenylbenzimidoyl chloride

Refernces

• 1、 Joseph, Devaneyan,Lee, Sunwoo,Park, Myeong Seong. "Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions". supporting information. p. 6227 - 6232. Retrieved 2021/07/28.
• 2、 Kim, Hyunwoo,Lee, Sunwoo,Shin, Taeil,Yang, Dahyeon. "Nickel/briphos-catalyzed transamidation of unactivated tertiary amides". supporting information. p. 6053 - 6057. Retrieved 2020/10/27.