Technology Process of 2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide
There total 11 articles about 2-[4-Amino-6-(3,3-dimethyl-butylamino)-[1,3,5]triazin-2-ylamino]-5-bromo-N-(3-bromomethyl-phenyl)-N-(4-tert-butyl-benzyl)-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; phosphorus tribromide;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
DOI:10.1021/jo951098g
- Guidance literature:
-
Multi-step reaction with 7 steps
1: SOCl2 / 2 h / Heating
2: Et3N / CH2Cl2; toluene / 2 h / Ambient temperature
3: 100 percent / NH2NH2 / methanol / 6 h / Heating
4: 1.) i-Pr2NEt, 2.) NH3 / 1.) THF, 0 deg C, 1.5 h, 2.) 1.5 h
5: 99 percent / i-Pr2NEt / tetrahydrofuran / 10 h / Heating
6: 84 percent / HOAc, H2O / tetrahydrofuran / 72 h / Ambient temperature
7: 92 percent / PBr3, pyridine / tetrahydrofuran / 1 h / 0 °C
With
pyridine; thionyl chloride; ammonia; water; phosphorus tribromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo951098g
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 93 percent / imidazole / dimethylformamide / 10 h / Ambient temperature
2: 50 percent / Et3N / tetrahydrofuran / 4 h / Heating
3: Et3N / CH2Cl2; toluene / 2 h / Ambient temperature
4: 100 percent / NH2NH2 / methanol / 6 h / Heating
5: 1.) i-Pr2NEt, 2.) NH3 / 1.) THF, 0 deg C, 1.5 h, 2.) 1.5 h
6: 99 percent / i-Pr2NEt / tetrahydrofuran / 10 h / Heating
7: 84 percent / HOAc, H2O / tetrahydrofuran / 72 h / Ambient temperature
8: 92 percent / PBr3, pyridine / tetrahydrofuran / 1 h / 0 °C
With
pyridine; 1H-imidazole; ammonia; water; phosphorus tribromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo951098g