tert-butyl 1-(3-amino-2-methylbenzyl)cyclopropanecarboxylate

Base Information

• Chemical Name: tert-butyl 1-(3-amino-2-methylbenzyl)cyclopropanecarboxylate
• CAS No.: 1192039-92-1
• Molecular Formula: C₁₆H₂₃NO₂
• Molecular Weight: 261.364
• Mol file: 1192039-92-1.mol

Synonyms:tert-butyl 1-(3-amino-2-methylbenzyl)cyclopropanecarboxylate

Chemical Property of tert-butyl 1-(3-amino-2-methylbenzyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(3-amino-2-methylbenzyl)cyclopropanecarboxylate

There total 2 articles about tert-butyl 1-(3-amino-2-methylbenzyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

tert-butyl 1-(2-methyl-3-nitrobenzyl)cyclopropanecarboxylate (1192039-91-0) → tert-butyl 1-(3-amino-2-methylbenzyl)cyclopropanecarboxylate (1192039-92-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2h;

Reference yield:

tert-butyl cyclopropanecarboxylate (87661-20-9) + 1-(bromomethyl)-2-methyl-3-nitrobenzene (39053-40-2) → tert-butyl 1-(3-amino-2-methylbenzyl)cyclopropanecarboxylate (1192039-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - -40 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C

With n-butyllithium; hydrogen; diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane;

upstream raw materials:

tert-butyl cyclopropanecarboxylate

1-(bromomethyl)-2-methyl-3-nitrobenzene

tert-butyl 1-(2-methyl-3-nitrobenzyl)cyclopropanecarboxylate

Refernces