KISSPEPTIN-10

Base Information

• Chemical Name: KISSPEPTIN-10
• CAS No.: 374675-21-5
• Molecular Formula: C63H83 N17 O14
• Molecular Weight: 1302.44
• Mol file: 374675-21-5.mol

Synonyms:16:PN: WO2004063221 SEQID: 16 claimed protein; 16: PN: WO2007072997 SEQID: 16claimed protein; 6: PN: WO03027149 SEQID: 6 claimed protein; Human kiss-10F;Human kisspeptin 10F; Human metastin 45-54; Kisspeptin-10 (human)

Chemical Property of KISSPEPTIN-10

Chemical Property:

• PKA: 9.96±0.15(Predicted)
• PSA: 535.34000
• Density: 1.46±0.1 g/cm3(Predicted)
• LogP: 3.51400
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water at 1mg/ml

Purity/Quality:

99% ^*data from raw suppliers

Metastin(45-54) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Metastin (45-54) is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.
• Uses: Metastin (45-54) amide has been used in progesterone release experiments from MA-10 cells. It has also been used to induce gonadal differentiation in clownfish. Metastin (45-54) is a potent and selective agonist of AXOR12 and hOT7T175.