Z-GLY-LEU-NH2

Base Information

• Chemical Name: Z-GLY-LEU-NH2
• CAS No.: 7535-72-0
• Molecular Formula: C16H23N3O4
• Molecular Weight: 321.376
• Mol file: 7535-72-0.mol

Synonyms:Carbamicacid, [[(1-carbamoyl-3-methylbutyl)carbamoyl]methyl]-, benzyl ester (7CI);Carbamic acid, [[(1-carbamoyl-3-methylbutyl)carbamoyl]methyl]-, benzyl ester,L- (8CI);Leucinamide, N-carboxyglycyl-, benzyl ester, L- (8CI);Benzyloxycarbonylglycyl-L-leucinamide;N-(Benzyloxycarbonyl)glycyl-L-leucinamide;N-Benzyloxycarbonylglycyl-L-leucineamide;N-Carbobenzoxy-glycyl-leucine amide;N-Carbobenzoxyglycyl-L-leucinamide;

Chemical Property of Z-GLY-LEU-NH2

Chemical Property:

• Boiling Point: 599.8 °C at 760 mmHg
• Flash Point: 316.6 °C
• PSA: 110.52000
• Density: 1.172 g/cm³
• LogP: 2.41110
• Storage Temp.: -15°C

Purity/Quality:

HPLC>98% ^*data from raw suppliers

Z-Gly-Leu-NH2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-GLY-LEU-NH2

There total 15 articles about Z-GLY-LEU-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

Z-Gly carbamoylmethyl ester (4816-85-7) + (2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) → (N-carboxybenzylglycinyl)leucinamide (7535-72-0)

Guidance literature:

With α-chymotrypsin immobilised on Celite; Tris buffer; triethylamine; In acetonitrile; at 30 ℃; for 48h; pH=7.8;

DOI:10.1039/b004180g

Reference yield: 80.0%

N-benzyloxycarbonylglycyl-L-leucine methyl ester (17331-93-0) → (N-carboxybenzylglycinyl)leucinamide (7535-72-0)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃; for 48h;

DOI:10.1002/anie.200703810

Reference yield: 74.3%

(2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + Z-Gly 2,2,2-trifluoroethyl ester (203640-50-0) → (N-carboxybenzylglycinyl)leucinamide (7535-72-0)

Guidance literature:

With α-chymotrypsin immobilised on Celite; Tris buffer; triethylamine; In acetonitrile; at 30 ℃; for 48h; pH=7.8;

DOI:10.1039/b004180g

upstream raw materials:

N-benzyloxycarbonylglycyl-L-leucine methyl ester

H-L-Leu-NH₂

Z-Gly-ONp

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

N-benzyloxycarbonylglycyl-L-leucine methyl ester

(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-4-methyl-pentanoic acid

methyl N-benzyloxycarbonylglycinate

N-(Benzyloxycarbonyl)glycine

Refernces

• 1、 Whitteck, John T.,Ni, Weijuan,Griffin, Benjamin M.,Eliot, Andrew C.,Thomas, Paul M.,Kelleher, Neil L.,Metcalf, William W.,Van Der Donk, Wilfred A.. "Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid". . p. 9089 - 9092. Retrieved 2008/09/20.
• 2、 Miyazawa, Toshifumi,Tanaka, Kayoko,Ensatsu, Eiichi,Yanagihara, Ryoji,Yamada, Takashi. "Broadening of the substrate tolerance of α-chymotrypsin by using the carbamoylmethyl ester as an acyl donor in kinetically controlled peptide synthesis". . p. 87 - 93. Retrieved 2007/10/03.