FMOC-ACPC-OH

Base Information

• Chemical Name: FMOC-ACPC-OH
• CAS No.: 126705-22-4
• Molecular Formula: C19H17NO4
• Molecular Weight: 323.348
• Hs Code.: 2924299090
• Mol file: 126705-22-4.mol

Synonyms:1-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]cyclopropanecarboxylicacid;

Chemical Property of FMOC-ACPC-OH

Chemical Property:

• Vapor Pressure: 1.09E-13mmHg at 25°C
• Melting Point: 225-226 °C
• Refractive Index: 1.671
• Boiling Point: 566.9 °C at 760 mmHg
• PKA: 3.97±0.20(Predicted)
• Flash Point: 296.7 °C
• PSA: 75.63000
• Density: 1.39 g/cm³
• LogP: 3.53320
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Fmoc-1-aminocyclopropane-1-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-ACPC-OH

There total 3 articles about FMOC-ACPC-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aminocyclopropane-1-carboxylic acid (22059-21-8) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 1-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)cyclopropanecarboxylic acid (126705-22-4)

Guidance literature:

With phosphate buffer; In N,N-dimethyl-formamide; at 0 ℃; for 24h; pH=9 - 10;

DOI:10.1021/ja0348391

Reference yield:

aminocyclopropane-1-carboxylic acid (22059-21-8) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 1-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)cyclopropanecarboxylic acid (126705-22-4)

Guidance literature:

aminocyclopropane-1-carboxylic acid; With sodium carbonate; In water; Inert atmosphere;

(fluorenylmethoxy)carbonyl chloride; In 1,4-dioxane; water; for 8h; Inert atmosphere;

DOI:10.1021/jacs.5b12557

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 1-Bromo-2-chloroethane (107-04-0) → 1-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)cyclopropanecarboxylic acid (126705-22-4)

Guidance literature:

Multistep reaction;

DOI:10.1016/j.tetlet.2003.09.119

upstream raw materials:

aminocyclopropane-1-carboxylic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(fluorenylmethoxy)carbonyl chloride

1-Bromo-2-chloroethane

Downstream raw materials:

C₂₁H₁₉FN₈O₂

Refernces

• 1、 Nicolaou,Yin, Jun,Mandal, Debashis,Erande, Rohan D.,Klahn, Philipp,Jin, Michael,Aujay, Monette,Sandoval, Joseph,Gavrilyuk, Julia,Vourloumis, Dionisios. "Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins". supporting information. p. 1698 - 1708. Retrieved 2016/02/20.
• 2、 O'Donnell, Martin J.,Alsina, Jordi,Scott, William L.. "Solid-phase synthesis and utilization of side-chain reactive unnatural amino acids". . p. 8403 - 8406. Retrieved 2007/10/03.