2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER

Base Information

• Chemical Name: 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER
• CAS No.: 128073-16-5
• Molecular Formula: C₉H₇ClF₃NO₂
• Molecular Weight: 253.608
• Hs Code.: 2933399090
• Mol file: 128073-16-5.mol

Synonyms:Ethyl5-(trifluoromethyl)-3-chloropyridine-2-carboxylate;

Chemical Property of 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0047mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 276.8 °C at 760 mmHg
• PKA: -3.19±0.10(Predicted)
• Flash Point: 121.2 °C
• PSA: 39.19000
• Density: 1.389 g/cm³
• LogP: 2.93050
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

Ethyl 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER

There total 4 articles about 2-PYRIDINECARBOXYLIC ACID, 3-CHLORO-5-(TRIFLUOROMETHYL)-, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 3-chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester (128073-16-5)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate; at 80 ℃; for 5h; under 11400.8 Torr; Reagent/catalyst; Temperature; Autoclave;

DOI:10.1021/op010012k

Reference yield: 87.6%

3-chloro-2-cyano-5-(trifluoromethyl)pyridine (80194-70-3) + ethanol (64-17-5) → 3-chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester (128073-16-5)

Guidance literature:

3-chloro-2-cyano-5-(trifluoromethyl)pyridine; ethanol; With pyridine; hydrogenchloride; at 0 - 80 ℃; for 19h;

In water; at 25 - 30 ℃; for 2h; Concentration; Temperature;

Reference yield: 85.0%

2,3-dichloro-5-trifluoromethylpyridine (69045-84-7) → 3-chloro-5-trifluoromethylpyridine-2-carboxylic acid ethyl ester (128073-16-5)

Guidance literature:

With carbon monoxide; triethylamine; In ethanol;

upstream raw materials:

2,3-dichloro-5-trifluoromethylpyridine

ethanol

carbon monoxide

3-chloro-2-cyano-5-(trifluoromethyl)pyridine

Downstream raw materials:

3-chloro-5-trifluoromethylpyridine-2-carboxylic acid

1-(3-chloro-5-trifluoromethylpyridin-2-yl)-3-cyclopropylpropan-13-dione

ethyl 3-methanesulfonyl-5-trifluoromethylpyridine-2-carboxylate

Refernces

• 1、 -. "HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES". Page/Page column 87. . Retrieved 2015/11/09.
• 2、 -. "Pyrazole derivatives as herbicides". . . Retrieved 2008/06/13.