6-Hydrazinonicotinic acid

Base Information

• Chemical Name: 6-Hydrazinonicotinic acid
• CAS No.: 133081-24-0
• Molecular Formula: C6H7N3O2
• Molecular Weight: 153.14
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80396352
• Nikkaji Number: J752.336J
• Wikidata: Q72482848
• Mol file: 133081-24-0.mol

Synonyms:6-hydrazinonicotinic acid

Chemical Property of 6-Hydrazinonicotinic acid

Chemical Property:

• Vapor Pressure: 5.65E-08mmHg at 25°C
• Melting Point: 0oC
• Refractive Index: 1.71
• Boiling Point: 424.8 °C at 760 mmHg
• PKA: 4.72±0.20(Predicted)
• Flash Point: 210.7 °C
• PSA: 88.24000
• Density: 1.504 g/cm³
• LogP: 0.83870
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: Aqueous Base (Slightly, Heated, Sonicated)
• XLogP3: -2.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 153.053826475
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Hydrazino-3-pyridinecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22-36/37/38:
• Hazard Codes: R20/21/22-36/37/38:
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1C(=O)O)NN

Technology Process of 6-Hydrazinonicotinic acid

There total 2 articles about 6-Hydrazinonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 6-hydrazinylnicotinic acid (133081-24-0) + 6-hydrazinonicotinic hydrazide (731005-24-6)

Guidance literature:

With hydrazine hydrate; at 120 - 125 ℃;

Reference yield:

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 6-hydrazinylnicotinic acid (133081-24-0) + 6-hydrazinonicotinic hydrazide (731005-24-6)

Guidance literature:

at 120 - 125 ℃;

Reference yield: 89.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 6-hydrazinylnicotinic acid (133081-24-0) + sodium 2-formylbenzenesulfonate (1008-72-6) → sodium succinimidyl 6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinate (186305-11-3)

Guidance literature:

6-hydrazinylnicotinic acid; sodium 2-formylbenzenesulfonate; at 20 ℃; for 3h;

1-hydroxy-pyrrolidine-2,5-dione; With dicyclohexyl-carbodiimide; at 20 ℃; for 19h; Reflux;

DOI:10.1016/j.ejmech.2019.112032

upstream raw materials:

6-Chloro-3-pyridinecarboxylic acid

Downstream raw materials:

6-({[(tert-butoxy)carbonyl]amino}amino)pyridine-3-carboxylic acid

6-hydroxy-3-pyridinecarboxylic acid

C₄₂H₄₆N₆O₉

2-(N'-tert-butoxycarbonylhydrazino)pyridine-5-carboxylic acid 2,5-dioxopyrrolidin-1-yl ester