Irbesartan hydrochloride

Base Information Edit

Chemical Name:Irbesartan hydrochloride
CAS No.:329055-23-4
Molecular Formula:C₂₅H₂₈N₆O*ClH
Molecular Weight:464.998
Hs Code.:
European Community (EC) Number:692-730-7
UNII:3OGC31WUMZ
DSSTox Substance ID:DTXSID30186568
Wikidata:Q27257817
Mol file:329055-23-4.mol

Synonyms:Irbesartan hydrochloride;Irbesartan HCl;329055-23-4;UNII-3OGC31WUMZ;3OGC31WUMZ;Irbesartan (hydrochloride);1,3-Diazaspiro(4.4)non-1-en-4-one, 2-butyl-3-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, hydrochloride (1:1);329055-23-4 (HCl);1,3-Diazaspiro(4.4)non-1-en-4-one, 2-butyl-3-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- hydrochloride;2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one;hydrochloride;SCHEMBL981096;HY-B0202A;DTXSID30186568;ZUYFSRQJPNUOQU-UHFFFAOYSA-N;BMS186295;AKOS040742186;IRBESARTAN HYDROCHLORIDE [WHO-DD];IRBESARTAN HYDROCHLORIDE [EMA EPAR];CS-0093512;Q27257817

Suppliers and Price of Irbesartan hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Irbesartan hydrochloride Edit

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:464.2091373
Heavy Atom Count:33
Complexity:682

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5.Cl

Technology Process of Irbesartan hydrochloride

There total 7 articles about Irbesartan hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 138401-24-8
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile

: 329055-23-4
2-n-butyl-4-spirocyclopentane-1-[((2'-tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride

Guidance literature:: 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile; With sodium azide; triethylamine hydrochloride; In 1-methyl-1H-imidazole; at 130 ℃; for 12h;

With sodium hydroxide; In 1-methyl-1H-imidazole; tert-butyl methyl ether; water; at 20 ℃;

With hydrogenchloride; sodium nitrite; In water; pH=< 1; Product distribution / selectivity;

Reference yield: 90.0%

: 141745-71-3
1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide

: 329055-23-4
2-n-butyl-4-spirocyclopentane-1-[((2'-tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride

Guidance literature:: 1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide; With sodium azide; acetic acid; In 1-methyl-1H-imidazole; at 160 ℃; for 24h;

With sodium hydroxide; In 1-methyl-1H-imidazole; water; at 20 ℃; pH=12 - 13;

With hydrogenchloride; In water; Product distribution / selectivity;