Technology Process of 1-(3-hydroxybenzyl)-2-methyl-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline
There total 9 articles about 1-(3-hydroxybenzyl)-2-methyl-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(3-benzyloxybenzyl)-2-methyl-6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline;
With
palladium 10% on activated carbon; hydrogen; acetic acid;
In
methanol;
at 20 ℃;
for 16h;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
DOI:10.1002/anie.201006268
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 16 h / 20 °C
With
palladium 10% on activated carbon; hydrogen; acetic acid; trichlorophosphate;
In
methanol; acetonitrile;
DOI:10.1002/anie.201006268
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium iodide; potassium hydroxide / ethanol / 16 h / 90 - 100 °C / Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere
3.1: sodium hydroxide / chloroform; water / 17 h / 0 - 20 °C
4.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere
4.2: 16 h / 0 - 20 °C / Inert atmosphere
5.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 16 h / 20 °C
With
oxalyl dichloride; palladium 10% on activated carbon; hydrogen; acetic acid; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; trichlorophosphate;
In
methanol; ethanol; chloroform; water; toluene; acetonitrile;
DOI:10.1002/anie.201006268