(S)-1,4-DIBROMO-2-BUTANOL

Base Information

• Chemical Name: (S)-1,4-DIBROMO-2-BUTANOL
• CAS No.: 64028-90-6
• Molecular Formula: C4H8Br2O
• Molecular Weight: 231.915
• Hs Code.: 29055998
• Mol file: 64028-90-6.mol

Synonyms:2-Butanol,1,4-dibromo-, (S)-;(S)-1,4-Dibromobutan-2-ol;

Chemical Property of (S)-1,4-DIBROMO-2-BUTANOL

Chemical Property:

• Appearance/Colour: clear light brown liquid
• Melting Point: 33-36 °C
• Refractive Index: 1.536-1.54
• Boiling Point: 220.1 °C at 760 mmHg
• Flash Point: 116.5 °C
• PSA: 20.23000
• Density: 1.951 g/cm³
• LogP: 1.52720
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(S)-1,4-Dibromobutan-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1,4-DIBROMO-2-BUTANOL

There total 5 articles about (S)-1,4-DIBROMO-2-BUTANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(2S,1'RS)-2-(1'-ethoxyethyloxy)-1,4-butanediyl bis(p-toluenesulfonate) (76494-96-7) → (S)-1,4-dibromo-2-butanol (64028-90-6,1360729-08-3)

Guidance literature:

With sodium hydrogencarbonate; copper(I) bromide; lithium bromide; In acetone; for 48h; Ambient temperature;

DOI:10.1002/hlca.19800630724

Reference yield: 35.0%

(R)-1,2,4-butanetriol (70005-88-8,6810-31-7) → (R)-1,4-dibromo-2-butanol (19398-47-1,64028-90-6,68295-81-8,1360729-08-3)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 17h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00207

Reference yield: 35.0%

(S)-1,2,4-butanetriol (42890-76-6,6810-31-7) → (S)-1,4-dibromo-2-butanol (64028-90-6,1360729-08-3)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 17h;

upstream raw materials:

(R)-1,2,4-butanetriol

(Ξ)-2-((S)-3-bromo-1-bromomethyl-propoxy)-tetrahydro-pyran

(2S,1'RS)-2-(1'-ethoxyethyloxy)-1,4-butanediyl bis(p-toluenesulfonate)

(S)-1,2,4-butanetriol

Downstream raw materials:

(3R)-1-{(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl}pyrrolidin-3-ol

Vernakalant hydrochloride

(S)-tert-butyl((1,4-dibromobutan-2-yl)oxy)diphenylsilane

(R)-4-bromo-1,2-butylene epoxide

Refernces

• 1、 -. "HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF". Paragraph 00170. . Retrieved 2015/12/30.
• 2、 -. "HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF". Paragraph 00144; 00155. . Retrieved 2014/10/15.