DOPAMINE HYDROCHLORIDE

Base Information

• Chemical Name: DOPAMINE HYDROCHLORIDE
• CAS No.: 335081-04-4
• Molecular Formula: C₈H₁₁NO₂*ClH
• Molecular Weight: 190.631
• Mol file: 335081-04-4.mol

Synonyms:3,4-DIHYDROXYPHENYL-ETHYLAMINE HYDROCHLORIDE;2-ethyl-1-13C-aMine HC;3,4-DIHYDROXYPHENETHYLAMINE,HCL;4-(2-AMINOETHYL)PYROCATECHOL HYDROCHLORIDE;3-HYDROXYTYRAMINIUM CHLORIDE;HYDROXYTYRAMINE HCL;DOPAMINE HCL;2-(3,4-DIHYDROXYPHENYL)ETHYL-1-13C-AMINE HCL;2-(1H-TETRAZOL-5-YL)-PHENOXY]-ACETIC ACID;

Chemical Property of DOPAMINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 248-250oC(lit.)
• PSA: 66.48000
• LogP: 2.10130
• Storage Temp.: 0-6°C
• Solubility.: alcohol: 20 mg/mL

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxytyraminium chloride for synthesis ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cardio Tonic 2-(3,4-Dihydroxyphenyl)ethyl-1-13C-amine HCl (CAS# 335081-04-4) is a useful isotopically labeled research compound.

Technology Process of DOPAMINE HYDROCHLORIDE

There total 6 articles about DOPAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(3,4-dimethoxyphenyl)<1-13C>ethylamine → <α-13C>dopamine hydrochloride (335081-04-4)

Guidance literature:

With hydrogenchloride; sodium hypophosphite; ion-exchanger Dowex 50 X₂-200; hydrogen bromide; isobutyric Acid; for 2h; Heating;

Reference yield: 50.0%

2(13)C-3,4-dihydroxy-β-nitrostyrene → 2(13)C-dopamine hydrochloride (1386948-31-7,335081-04-4)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; water; for 3h; Cooling with ice;

DOI:10.1021/ja305051u

Reference yield: 3.8%

C21(13)CH19(15)NO2 → C7(13)CH11(15)NO2*ClH (335081-04-4)

Guidance literature:

With chloroform; 20% palladium hydroxide-activated charcoal; hydrogen; In ethanol; at 0 - 50 ℃; Inert atmosphere;

upstream raw materials:

2-(3,4-dimethoxyphenyl)<1-13C>acetonitrile

benzene-1,2-diol

Refernces

• 1、 Ueki, Ryosuke,Yamaguchi, Koya,Nonaka, Hiroshi,Sando, Shinsuke. "1H NMR probe for in situ monitoring of dopamine metabolism and its application to inhibitor screening". supporting information; experimental part. p. 12398 - 12401. Retrieved 2012/08/29.
• 2、 Mueller, Martin J.,Zenk, Meinhart H.. "The Biosynthesis of the Cularine Alkaloids". . p. 557 - 564. Retrieved 2007/10/02.