Technology Process of (R)-ethyl 2-bromo-4-phenylbutyrate
There total 3 articles about (R)-ethyl 2-bromo-4-phenylbutyrate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 45 percent / methanol; H2O / 8 h / 70 °C
2: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9
3: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h
4: 95 percent / SOCl2 / 24 h / Ambient temperature
With
thionyl chloride; sulfuric acid; ammonium chloride; potassium bromide; sodium nitrite;
In
methanol; ammonium hydroxide; water;
DOI:10.1248/cpb.37.280
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9
2: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h
3: 95 percent / SOCl2 / 24 h / Ambient temperature
With
thionyl chloride; sulfuric acid; ammonium chloride; potassium bromide; sodium nitrite;
In
ammonium hydroxide;
DOI:10.1248/cpb.37.280
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h
2: 95 percent / SOCl2 / 24 h / Ambient temperature
With
thionyl chloride; sulfuric acid; potassium bromide; sodium nitrite;
DOI:10.1248/cpb.37.280
