2-Chloro-5-iodobenzoyl chloride

Base Information

• Chemical Name: 2-Chloro-5-iodobenzoyl chloride
• CAS No.: 281652-58-2
• Molecular Formula: C₇H₃Cl₂IO
• Molecular Weight: 300.911
• UNII: MF46VVD5RA
• Mol file: 281652-58-2.mol

Synonyms:2-chloro-5-iodobenzoyl chloride;281652-58-2;Benzoyl chloride, 2-chloro-5-iodo-;2-chloro-5-iodo-benzoyl Chloride;MF46VVD5RA;2-chloro-5-iodobenzoylchloride;SCHEMBL1934879;5-iodo-2-chlorobenzoyl chloride;CRBYUOHFEZMJTE-UHFFFAOYSA-N;AKOS000289072;BS-53112;A876773

Chemical Property of 2-Chloro-5-iodobenzoyl chloride

Chemical Property:

• Boiling Point: 309.9±27.0 °C(Predicted)
• Density: 2.007±0.06 g/cm3(Predicted)
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 299.86057
• Heavy Atom Count: 11
• Complexity: 163

Purity/Quality:

99.3% ^*data from raw suppliers

2-CHLORO-5-IODOBENZOYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1I)C(=O)Cl)Cl

Technology Process of 2-Chloro-5-iodobenzoyl chloride

There total 2 articles about 2-Chloro-5-iodobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-5-iodobenzoic acid (19094-56-5) → 2-chloro-5-iodobenzoylchloride (281652-58-2)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 10 - 25 ℃; for 16h;

Reference yield:

oxalyl dichloride (79-37-8) + 2-chloro-5-iodobenzoic acid (19094-56-5) → 2-chloro-5-iodobenzoylchloride (281652-58-2)

Guidance literature:

N,N-dimethyl-formamide; In dichloromethane; for 20.9333h;

Reference yield: 100.0%

2-chloro-5-iodobenzoylchloride (281652-58-2) + ethyl (E)-3-(dimethylamino)acrylate (1117-37-9) → ethyl 2-(2-chloro-5-iodobenzoyl)-3-(dimethylamino)acrylate

Guidance literature:

With triethylamine; In toluene; at 90 ℃; for 2h;

DOI:10.1016/j.bmc.2014.05.028

upstream raw materials:

2-chloro-5-iodobenzoic acid

oxalyl dichloride

Downstream raw materials:

2-chloro-5-iodo-N-[4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-benzamide

2-chloro-5-iodo-N-(tricyclo[3.3.1.1^3,7]dec-1-ylmethyl)benzamide

(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone

2-chloro-N-cyclopentyl-5-iodo-benzamide

Refernces

• 1、 Vaňková, Karolína,Rahm, Michal,Choutka, Jan,Pohl, Radek,Parkan, Kamil. "Facile Approach to C-Glucosides by Using a Protecting-Group-Free Hiyama Cross-Coupling Reaction: High-Yielding Dapagliflozin Synthesis". supporting information. p. 10583 - 10588. Retrieved 2021/06/25.
• 2、 -. "GLUCOPYRANOSE DERIVATIVES USEFUL AS SGLT2 INHIBITORS". Page/Page column 61. . Retrieved 2020/06/10.