2-(2-methoxyphenoxy)-ethyl methanesulphonate

Base Information

• Chemical Name: 2-(2-methoxyphenoxy)-ethyl methanesulphonate
• CAS No.: 122853-43-4
• Molecular Formula: C₁₀H₁₄O₅S
• Molecular Weight: 246.284
• Mol file: 122853-43-4.mol

Synonyms:2-(2-methoxyphenoxy)-ethyl methanesulphonate

Chemical Property of 2-(2-methoxyphenoxy)-ethyl methanesulphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-methoxyphenoxy)-ethyl methanesulphonate

There total 4 articles about 2-(2-methoxyphenoxy)-ethyl methanesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-methoxyphenoxy)ethanol (18181-71-0) + methanesulfonyl chloride (124-63-0) → 2-(2-methoxyphenoxy)-ethyl methanesulphonate (122853-43-4)

Guidance literature:

2-(2-methoxyphenoxy)ethanol; With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

methanesulfonyl chloride; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.04.028

Reference yield:

2(2-methoxyphenoxy)ethanale (18167-91-4) → 2-(2-methoxyphenoxy)-ethyl methanesulphonate (122853-43-4)

Guidance literature:

With sodium borohydrid; In methanol; aqueous NaH₂PO₄;

Reference yield:

2-methoxy-phenol (90-05-1) → 2-(2-methoxyphenoxy)-ethyl methanesulphonate (122853-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 3 h / Reflux

2.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1016/j.bmc.2016.04.028

upstream raw materials:

2(2-methoxyphenoxy)ethanale

2-methoxy-phenol

2-(2-methoxyphenoxy)ethanol

methanesulfonyl chloride

Downstream raw materials:

1-(3-pyridyl)-2-thia-4-(2-methoxy-phenoxy) butane

Refernces

• 1、 -. "N-ARYLOXYALKYL TRYPTAMINE ALPHA1-ADRENERGIC RECEPTOR ANTAGONISTS". . . Retrieved 2008/06/13.
• 2、 -. "Ethers and thioethers having therapeutical activity, their preparation and pharmaceutical compositions containing them". . . Retrieved 2008/06/13.