Technology Process of 11-methyl-6-(p-tolyl)-11H-indolo[3,2-c]quinoline
There total 3 articles about 11-methyl-6-(p-tolyl)-11H-indolo[3,2-c]quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-methyl-2-phenyl-1H-indole-3-carbonitrile; para-methylphenylmagnesium bromide;
In
tetrahydrofuran-d8;
at 0 - 90 ℃;
for 36h;
Inert atmosphere;
Schlenk technique;
With
oxygen; copper diacetate;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
at 100 ℃;
for 48h;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/adsc.201301073
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: zinc trifluoromethanesulfonate / 0.05 h / 20 °C / Inert atmosphere; Schlenk technique
1.2: 40 h / 100 °C / Inert atmosphere; Schlenk technique
2.1: tetrahydrofuran-d8 / 36 h / 0 - 90 °C / Inert atmosphere; Schlenk technique
2.2: 48 h / 100 °C / Inert atmosphere; Schlenk technique
With
zinc trifluoromethanesulfonate;
In
tetrahydrofuran-d8;
DOI:10.1002/adsc.201301073
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide; tetrabutylammonium tetrafluoroborate; tri(p-bromophenyl)amine / acetonitrile; water / 7 h / 20 °C / Inert atmosphere; Electrolysis
2: copper diacetate; oxygen / N,N-dimethyl-formamide; methanol; tetrahydrofuran / 7 h / 20 °C / Inert atmosphere; Electrolysis
With
tri(p-bromophenyl)amine; tetrabutylammonium tetrafluoroborate; oxygen; copper diacetate; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.orglett.1c02063
