1,4-Bis(chloromethyl)-2,3,5,6-tetrafluorobenzene

Base Information

• Chemical Name: 1,4-Bis(chloromethyl)-2,3,5,6-tetrafluorobenzene
• CAS No.: 131803-37-7
• Molecular Formula: C8H4Cl2F4
• Molecular Weight: 247.019
• Hs Code.: 2903999090
• European Community (EC) Number: 671-802-1
• DSSTox Substance ID: DTXSID70373495
• Nikkaji Number: J1.853.826A
• Wikidata: Q82161691
• Mol file: 131803-37-7.mol

Synonyms:131803-37-7;1,4-bis(chloromethyl)-2,3,5,6-tetrafluorobenzene;1,4-Bis(chloromethyl)tetrafluorobenzene;Benzene, 1,4-bis(chloromethyl)-2,3,5,6-tetrafluoro-;1,4-bis(chloromethyl)-2,3,5,6-tetrafluoro-benzene;SCHEMBL2522605;DTXSID70373495;MFCD03424467;AKOS005254335;FT-0643161;A806313

Chemical Property of 1,4-Bis(chloromethyl)-2,3,5,6-tetrafluorobenzene

Chemical Property:

• Vapor Pressure: 0.147mmHg at 25°C
• Melting Point: 77 °C
• Refractive Index: 1.477
• Boiling Point: 222.959 °C at 760 mmHg
• Flash Point: 100.992 °C
• PSA: 0.00000
• Density: 1.528 g/cm³
• LogP: 3.72060
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 245.9626182
• Heavy Atom Count: 14
• Complexity: 156

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4-Bis(chloromethyl)tetrafluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1=C(C(=C(C(=C1F)F)CCl)F)F)Cl

Technology Process of 1,4-Bis(chloromethyl)-2,3,5,6-tetrafluorobenzene

There total 2 articles about 1,4-Bis(chloromethyl)-2,3,5,6-tetrafluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.59%

2,3,5,6-tetrafluoroterephthalic acid (652-36-8) → α,α'-dichloro-2,3,5,6-tetrafluoro-1,4-xylene (131803-37-7)

Guidance literature:

With thionyl chloride; In dichloromethane; for 2h; Reflux;

Reference yield: 97.0%

2,3,5,6-tetrafluoro-1,4-benzenedimethanol (92339-07-6) → α,α'-dichloro-2,3,5,6-tetrafluoro-1,4-xylene (131803-37-7)

Guidance literature:

With thionyl chloride; for 5h; Heating;

DOI:10.1016/S0022-1139(00)82182-X

Reference yield: 100.0%

1H-imidazole (288-32-4) + α,α'-dichloro-2,3,5,6-tetrafluoro-1,4-xylene (131803-37-7) → 2,3,5,6-tetrafluoro-1,4-bis(imidazole-1-yl-methyl)benzene (876148-50-4)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 6h;

DOI:10.1039/c4gc00730a

upstream raw materials:

2,3,5,6-tetrafluoro-1,4-benzenedimethanol

2,3,5,6-tetrafluoroterephthalic acid

Downstream raw materials:

2,3,5,6-tetrafluoro-1,4-xylene-α,α'bis(diethylsulphonium chloride)

2,3,5,6-tetrafluoro-1,4-bis(imidazole-1-yl-methyl)benzene

α,α’-dibromo-m-tetrafluoroxylene

2,3,5,6-tetrafluoro-1,4-benzenedimethanol

Refernces

• 1、 Brooke, Gerald M.,Mawson, Simon D.. "THE ATTEMPTED SYNTHESIS OF POLYPARATETRAFLUOROPHENYLENE VINYLENE VIA WATERSOLUBLE AND ORGANIC SOLVENT-SOLUBLE PRECURSOR POLYMERS". . p. 101 - 109. Retrieved 2007/10/02.