2-FLUORO-4-(TRIFLUOROMETHYL)PHENOL

Base Information

• Chemical Name: 2-FLUORO-4-(TRIFLUOROMETHYL)PHENOL
• CAS No.: 77227-78-2
• Molecular Formula: C₇H₄F₄O
• Molecular Weight: 180.102
• Mol file: 77227-78-2.mol

Synonyms:2-Fluoro-4-(trifluoromethyl)phenol;3-Fluoro-4-hydroxybenzotrifluoride;

Chemical Property of 2-FLUORO-4-(TRIFLUOROMETHYL)PHENOL

Chemical Property:

• Boiling Point: 164.7 °C at 760 mmHg
• PKA: 7.31±0.18(Predicted)
• Flash Point: 53.4 °C
• PSA: 20.23000
• Density: 1.434 g/cm³
• LogP: 2.55010
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-4-(trifluoromethyl)phenol ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-4-(TRIFLUOROMETHYL)PHENOL

There total 3 articles about 2-FLUORO-4-(TRIFLUOROMETHYL)PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-fluoro-2-nitrobenzoate (393-85-1) → 2-fluoro-4-trifluoromethyl phenol (77227-78-2)

Guidance literature:

In dimethyl sulfoxide;

Reference yield:

4-hydroxybenzotrifluoride (402-45-9) → 2-fluoro-4-trifluoromethyl phenol (77227-78-2) + 2,6-difluoro-4-trifluoromethyl-phenol

Guidance literature:

With formic acid; fluorine; at 10 ℃; for 1.75h; Title compound not separated from byproducts;

DOI:10.1016/S0022-1139(99)00238-9

Reference yield:

→ 2-fluoro-4-trifluoromethyl phenol (77227-78-2)

Guidance literature:

upstream raw materials:

4-hydroxybenzotrifluoride

methyl 5-fluoro-2-nitrobenzoate

Refernces

• 1、 -. "Substituted diphenyl ethers". . . Retrieved 2008/06/13.