C₂₀H₂₁FN₆O₃S

Base Information

• Chemical Name: C₂₀H₂₁FN₆O₃S
• CAS No.: 1609529-45-4
• Molecular Formula: C₂₀H₂₁FN₆O₃S
• Molecular Weight: 444.49
• Mol file: 1609529-45-4.mol

Synonyms:C₂₀H₂₁FN₆O₃S

Chemical Property of C₂₀H₂₁FN₆O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₁FN₆O₃S

There total 3 articles about C₂₀H₂₁FN₆O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

C15H17ClN4O3S (1609531-17-0) + 2-amino-5-fluoropyridine (21717-96-4) → C20H21FN6O3S (1609529-45-4)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl acetamide; at 145 ℃; for 1.5h; Inert atmosphere;

Reference yield:

4,6-dichloro-nicotinic acid (73027-79-9) → C20H21FN6O3S (1609529-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 1 h / 150 °C / Microwave irradiation; Sealed tube; Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl acetamide / 1.5 h / 145 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxalyl dichloride; sodium hexamethyldisilazane; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

4,6-dichloro-N-methylnicotinamide (1609530-95-1) + 2-amino-N,N-dimethyl-benzenesulfonamide (54468-86-9) → C20H21FN6O3S (1609529-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 1 h / 150 °C / Microwave irradiation; Sealed tube; Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / N,N-dimethyl acetamide / 1.5 h / 145 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;

upstream raw materials:

C₁₅H₁₇ClN₄O₃S

2-amino-5-fluoropyridine

4,6-dichloro-nicotinic acid

4,6-dichloro-N-methylnicotinamide

Refernces