1,5-DIPHENYL-1H-PYRAZOLE

Base Information

• Chemical Name: 1,5-DIPHENYL-1H-PYRAZOLE
• CAS No.: 6831-89-6
• Molecular Formula: C15H12N2
• Molecular Weight: 220.274
• Hs Code.: 2933199090
• Mol file: 6831-89-6.mol

Synonyms:Pyrazole,1,5-diphenyl- (6CI,7CI,8CI);1,5-Diphenylpyrazole;

Chemical Property of 1,5-DIPHENYL-1H-PYRAZOLE

Chemical Property:

• Vapor Pressure: 1.51E-05mmHg at 25°C
• Melting Point: 100-103℃
• Refractive Index: 1.613
• Boiling Point: 377 °C at 760 mmHg
• Flash Point: 181.8 °C
• PSA: 17.82000
• Density: 1.07 g/cm³
• LogP: 3.53930
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-methyl-5-phenyl-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,5-DIPHENYL-1H-PYRAZOLE

There total 68 articles about 1,5-DIPHENYL-1H-PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

cinnamaldehyde phenylhydrazone (1216-15-5) → 1,5-diphenyl-1H-pyrazole (6831-89-6)

Guidance literature:

With thianthrene cation radical perchlorate; In acetonitrile;

DOI:10.1021/jo00244a024

Reference yield: 91.0%

(E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one (1131-80-2,1201-93-0,31919-75-2) + phenylhydrazine hydrochloride (59-88-1) → 1,5-diphenyl-1H-pyrazole (6831-89-6)

Guidance literature:

With sodium carbonate; acetic acid; In methanol; water; at 135 ℃; for 2h; pH=4; regioselective reaction;

DOI:10.1021/jo902257j

Reference yield: 90.0%

1-phenyl-3-dimethylaminoprop-2-enone (1201-93-0) + phenylhydrazine (100-63-0) → 1,5-diphenyl-1H-pyrazole (6831-89-6)

Guidance literature:

With C₂₄H₃₅N₂O₆⁽¹⁺⁾*HO₄S^(1-); at 50 ℃; for 0.333333h; Green chemistry;

DOI:10.1007/s11164-014-1782-7

upstream raw materials:

1,5-diphenyl-4-pyrazolin-3-one

1,5-diphenylpyrazole-3-carboxylic acid

1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid

3-oxo-3-phenyl-propionaldehyde phenylhydrazone

Downstream raw materials:

1-methyl-2,3-diphenyl-pyrazolium; iodide

4-Benzoyl-1,5-diphenyl-pyrazol

Refernces

• 1、 Pise, Ashok S.,Burungale, Arvind S.,Devkate, Santosh S.. "Ultrasound assisted synthesis of 1,5-disubstituted pyrazole using Cu(I) catalyst". . p. 575 - 579. Retrieved 2020/02/06.
• 2、 Kaufmann, Julia,J?ckel, Elisabeth,Haak, Edgar. "Ruthenium-catalyzed formation of pyrazoles or 3-hydroxynitriles from propargyl alcohols and hydrazines". supporting information. p. 91 - 101. Retrieved 2019/07/09.