Technology Process of 2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide
There total 4 articles about 2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5,8-dicarboxylic acid 5-{[1-(4-fluoro-phenyl)-cyclopropyl]-amide} 8-hydroxyamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride;
In
tetrahydrofuran; water;
for 3h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium chlorite / water; tert-butyl alcohol
2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
3: hydroxylamine hydrochloride / tetrahydrofuran; water / 3 h / Reflux
With
sodium chlorite; hydroxylamine hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
2: hydroxylamine hydrochloride / tetrahydrofuran; water / 3 h / Reflux
With
hydroxylamine hydrochloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
