N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate

Base Information

• Chemical Name: N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate
• CAS No.: 880595-55-1
• Molecular Formula: C₁₂H₁₆Cl₂F₂NOP
• Molecular Weight: 330.142
• Mol file: 880595-55-1.mol

Synonyms:N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate

Chemical Property of N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate

There total 3 articles about N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H5Cl2F2OP (945011-65-4) + N-methyl-N-(4-chloro-n-butyl)amine hydrochloride → N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate (880595-55-1)

Guidance literature:

With triethylamine; In dichloromethane; at -78 ℃; for 20h;

DOI:10.1021/jm061146x

Reference yield:

diethyl benzoylphosphonate (3277-27-8) → N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate (880595-55-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 42 percent / (diethylamino)sulfur trifluoride / 21 h / 0 - 20 °C

2: SOCl₂; pyridine / 120 h / Heating

3: 0.18 g / Et₃N / CH₂Cl₂ / 20 h / -78 °C

With pyridine; thionyl chloride; diethylamino-sulfur trifluoride; triethylamine; In dichloromethane;

DOI:10.1021/jm061146x

Reference yield:

diethyl α,α-difluoromethyl-α-(phenyl)phosphonate (174349-94-1) → N-methyl-N-(4-chlorobutyl) difluoromethylphentlphosphonamidochloridate (880595-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂; pyridine / 120 h / Heating

2: 0.18 g / Et₃N / CH₂Cl₂ / 20 h / -78 °C

With pyridine; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jm061146x

upstream raw materials:

C₇H₅Cl₂F₂OP

diethyl benzoylphosphonate

diethyl α,α-difluoromethyl-α-(phenyl)phosphonate

Refernces

• 1、 -. "PRODRUGS OF DRUG-PHOSPHATE CONJUGATES AND ANALOGS THEREOF". Page/Page column 28. . Retrieved 2010/10/20.